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Crizotinib

Synonyms

SourcesNames Used
CCLE, GRAYPF-2341066
GDSC1000, FIMMCrizotinib
gCSI, CTRPv2crizotinib
PharmacoGx Crizotinib

External IDs

DatabaseIdentifier
Smiles: CC(C1=C(C=C(C=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
Inchikey: SCJHEFQWKWHQTO-GFCCVEGCSA-N
Pubchem: 54613769

Annotated Targets

MET, ALK

FDA Approval Status

Approved
Dataset Select
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Top molecular features associated with response to Crizotinib


Feature TypeStandardized
Nominal ANOVA
mRNA ALK GDSC1000 pan-cancer AAC 0.54 2e-28
mRNA IL26 GDSC1000 pan-cancer AAC 0.39 2e-15
mRNA TMPRSS11D GDSC1000 pan-cancer AAC 0.38 2e-14
mRNA SOCS3 GDSC1000 pan-cancer AAC 0.37 6e-14
mRNA GZMB GDSC1000 pan-cancer AAC 0.36 2e-13
mRNA ZBTB46 GDSC1000 pan-cancer AAC 0.35 2e-12
mRNA CD300C GDSC1000 pan-cancer AAC 0.35 1e-11
mRNA NOD2 GDSC1000 pan-cancer AAC 0.35 1e-11
mRNA SLC26A4 GDSC1000 pan-cancer AAC 0.33 2e-11
mRNA PFKFB3 GDSC1000 pan-cancer AAC 0.35 3e-11
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