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Broad-Novartis Cancer Cell Line Encyclopedia (CCLE)


The Cancer Cell Line Encyclopedia (CCLE) project is a collaboration between the Broad Institute, the Novartis Institutes for Biomedical Research, and its Genomics Institute of the Novartis Research Foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models, to develop integrated computational analyses that link distinct pharmacologic vulnerabilities to genomic patterns and to translate cell line integrative genomics into cancer patient stratification. The CCLE provides public access to genomic data as well as analysis and visualization for about 1000 cell lines.


CCLE website

RNA-seq on NCI Genomic Data Commons


The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity, Nature 2012

Data type

Data Type Assay/Platform Raw Processed
Pharmacological CellTiter Glo Yes AUC, IC50
mRNA Expression Affymetrix HG-U133PLUS2 Yes BrainArray, RMA
Illumina RNA-seq Yes No
DNA Copy Number Affymetrix SNP 6.0 Yes Birdseed, Normalized log2 ratios
DNA Mutation OncoMap No MAF
Hybrid Capture Yes MAF


PharmacoSet object for: CCLE