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AZD6244

Synonyms

SourcesNames Used
CCLE, GRAY, UHNBreastAZD6244
GDSC1000, CTRPv2selumetinib
FIMMSelumetinib
PharmacoGx AZD6244

External IDs

DatabaseIdentifier
Smiles: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
Inchikey: CYOHGALHFOKKQC-UHFFFAOYSA-N
Pubchem: 10127622

FDA Approval Status

Not Approved
Number of cell lines tested with AZD6244(per dataset)01002003004005006007008009001k# cell lines gCSIUHNBreastGRAYFIMMCCLECTRPv2GDSC100001350505038231001
Number of tissues tested with AZD6244(per dataset)05101520253035# tissues gCSIGRAYUHNBreastFIMMCCLECTRPv2GDSC10000114222535
Dataset Select
AZD6244: AACAAC0.000.100.200.300.400.500.600.70SNU-620SNU-620KMS-21BMKMS-21BMHCC-1588HCC-1588CHP-212CHP-212OCI-AML3OCI-AML3HuT 78HuT 78WM-88WM-88SIG-M5SIG-M5Malme-3MMalme-3MU-BLC1U-BLC1SNU-1079SNU-1079OCI-AML2OCI-AML2YD-10BYD-10BIPC-298IPC-298COLO-205COLO-205WM-983BWM-983BBT286BT286KMS-27KMS-27COLO 201COLO 201SH-4SH-4K052K052SNU-478SNU-478MEL-HOMEL-HOMOLM-6MOLM-6OCUM-1OCUM-1JK-1JK-1LB2518-MELLB2518-MELSNU-878SNU-878MMAC-SFMMAC-SFSNU-761SNU-761 ZR-75-30ZR-75-30MY-M12MY-M12HuO-3N1HuO-3N1EW-24EW-24EB-3EB-3NCI-H1876NCI-H1876NCI-H2141NCI-H2141PA-1PA-1LB647-SCLCLB647-SCLCMN-60MN-60DaudiDaudiNB14NB14IST-MES2IST-MES2NCC021NCC021KRIJKRIJOCI-LY-7OCI-LY-7BL-41BL-41COR-L95COR-L95NCI-H526NCI-H526NCI-H69NCI-H69TKTKCHP-126CHP-126MKN28MKN28NCI-H446NCI-H446JHOM-1JHOM-1NCI-H64NCI-H64EB2EB2MFE-280MFE-280P32-ISHP32-ISHLU-134-ALU-134-ASNU-620KMS-21BMHCC-1588CHP-212OCI-AML3HuT 78WM-88SIG-M5Malme-3MU-BLC1SNU-1079OCI-AML2YD-10BIPC-298COLO-205WM-983BBT286KMS-27COLO 201SH-4K052SNU-478MEL-HOMOLM-6OCUM-1JK-1LB2518-MELSNU-878MMAC-SFSNU-761 ZR-75-30MY-M12HuO-3N1EW-24EB-3NCI-H1876NCI-H2141PA-1LB647-SCLCMN-60DaudiNB14IST-MES2NCC021KRIJOCI-LY-7BL-41COR-L95NCI-H526NCI-H69TKCHP-126MKN28NCI-H446JHOM-1NCI-H64EB2MFE-280P32-ISHLU-134-ASNU-620: 0.75Synonyms: SNU-620, SNU620KMS-21BM: 0.72Synonyms: KMS-21BM, KMS21BMHCC-1588: 0.71Synonyms: HCC-1588, HCC1588CHP-212: 0.71Synonyms: CHP-212, CHP212OCI-AML3: 0.67Synonyms: OCI-AML3, OCIAML3HuT 78: 0.66Synonyms: HuT 78, HuT_78, HUT78WM-88: 0.64Synonyms: WM-88, WM88SIG-M5: 0.64Synonyms: SIG-M5, SIGM5Malme-3M: 0.63Synonyms: Malme-3M, MALME3MU-BLC1: 0.62Synonyms: U-BLC1, UBLC1SNU-1079: 0.60Synonyms: SNU-1079, SNU1079OCI-AML2: 0.57Synonyms: OCI-AML2, OCIAML2YD-10B: 0.57Synonyms: YD-10B, YD10BIPC-298: 0.56Synonyms: IPC-298, IPC298COLO-205: 0.56Synonyms: COLO-205, COLO 205, COLO205WM-983B: 0.54Synonyms: WM-983B, WM983BBT286: 0.54Synonyms: BT286KMS-27: 0.53Synonyms: KMS-27, KMS27COLO 201: 0.53Synonyms: COLO 201, COLO_201, COLO201SH-4: 0.53Synonyms: SH-4, SH4K052: 0.53Synonyms: K052, KO52SNU-478: 0.51Synonyms: SNU-478, SNU478MEL-HO: 0.51Synonyms: MEL-HO, MELHOMOLM-6: 0.50Synonyms: MOLM-6, MOLM6OCUM-1: 0.50Synonyms: OCUM-1, OCUM1JK-1: 0.50Synonyms: JK-1, JK1LB2518-MEL: 0.49Synonyms: LB2518-MELSNU-878: 0.49Synonyms: SNU-878, SNU878MMAC-SF: 0.49Synonyms: MMAC-SFSNU-761: 0.49Synonyms: SNU-761, SNU761 : 0.00Synonyms: : 0.00Synonyms: : 0.00Synonyms: : 0.00Synonyms: : 0.00Synonyms: ZR-75-30: 0.01Synonyms: ZR-75-30, ZR7530, zr7530MY-M12: 0.01Synonyms: MY-M12HuO-3N1: 0.01Synonyms: HuO-3N1EW-24: 0.01Synonyms: EW-24EB-3: 0.01Synonyms: EB-3NCI-H1876: 0.01Synonyms: NCI-H1876NCI-H2141: 0.01Synonyms: NCI-H2141, NCIH2141PA-1: 0.01Synonyms: PA-1LB647-SCLC: 0.01Synonyms: LB647-SCLCMN-60: 0.00Synonyms: MN-60Daudi: 0.00Synonyms: Daudi, DAUDINB14: 0.00Synonyms: NB14IST-MES2: 0.00Synonyms: IST-MES2NCC021: 0.00Synonyms: NCC021KRIJ: 0.00Synonyms: KRIJOCI-LY-7: 0.00Synonyms: OCI-LY-7, OCI-LY7BL-41: 0.00Synonyms: BL-41, BL41COR-L95: 0.00Synonyms: COR-L95, CORL95NCI-H526: 0.00Synonyms: NCI-H526, NCIH526NCI-H69: 0.00Synonyms: NCI-H69, NCIH69TK: 0.00Synonyms: TKCHP-126: 0.00Synonyms: CHP-126, CHP126MKN28: 0.00Synonyms: MKN28NCI-H446: 0.00Synonyms: NCI-H446, NCIH446JHOM-1: 0.00Synonyms: JHOM-1, JHOM1NCI-H64: 0.00Synonyms: NCI-H64EB2: 0.00Synonyms: EB2MFE-280: 0.00Synonyms: MFE-280P32-ISH: 0.00Synonyms: P32-ISHLU-134-A: 0.00Synonyms: LU-134-A0.005.0010.0015.0020.0025.00MHH-PREB-1MHH-PREB-1D-392MGD-392MGHC-1HC-1PCI-30PCI-30U-698-MU-698-MSU.86.86SU.86.86ES8ES8VMRC-MELGVMRC-MELGKHM-1BKHM-1BA431A431EW-3EW-3TASK1TASK1A704A704CRO-AP2CRO-AP2KYSE-220KYSE-220JURKATJURKATSNU-1041SNU-1041OCUB-MOCUB-MKARPAS-422KARPAS-422NCI-H1155NCI-H1155NCI-H1703NCI-H1703HEC-1HEC-1SK-MEL-31SK-MEL-31OSC-19OSC-19IA-LMIA-LMEW-16EW-16Hs 683Hs 683CTB-1CTB-1KNS-42KNS-42HEC-265HEC-265 WM-88WM-88DU-4475DU-4475HTC-C3HTC-C3Malme-3MMalme-3MKMOE-2KMOE-2LB2518-MELLB2518-MELIPC-298IPC-298CP50-MEL-BCP50-MEL-BMEL-HOMEL-HOJVM-2JVM-2UACC-62UACC-62NB4NB4SNU-620SNU-620OCUM-1OCUM-1HuT 78HuT 78HCC2998HCC2998NUGC-4NUGC-4CL-34CL-34YD-10BYD-10BM14M14K5K5OCI-AML3OCI-AML3NU-DUL-1NU-DUL-1K2K2CHP-212CHP-212BB49-HNCBB49-HNCSIG-M5SIG-M5G-MELG-MELMMAC-SFMMAC-SFOCI-AML2OCI-AML2MHH-PREB-1D-392MGHC-1PCI-30U-698-MSU.86.86ES8VMRC-MELGKHM-1BA431EW-3TASK1A704CRO-AP2KYSE-220JURKATSNU-1041OCUB-MKARPAS-422NCI-H1155NCI-H1703HEC-1SK-MEL-31OSC-19IA-LMEW-16Hs 683CTB-1KNS-42HEC-265 WM-88DU-4475HTC-C3Malme-3MKMOE-2LB2518-MELIPC-298CP50-MEL-BMEL-HOJVM-2UACC-62NB4SNU-620OCUM-1HuT 78HCC2998NUGC-4CL-34YD-10BM14K5OCI-AML3NU-DUL-1K2CHP-212BB49-HNCSIG-M5G-MELMMAC-SFOCI-AML2MHH-PREB-1: 27.59 (log10 µM)Synonyms: MHH-PREB-1D-392MG: 23.63 (log10 µM)Synonyms: D-392MGHC-1: 20.09 (log10 µM)Synonyms: HC-1PCI-30: 17.41 (log10 µM)Synonyms: PCI-30U-698-M: 17.35 (log10 µM)Synonyms: U-698-MSU.86.86: 15.50 (log10 µM)Synonyms: SU.86.86, SU8686ES8: 14.33 (log10 µM)Synonyms: ES8VMRC-MELG: 13.17 (log10 µM)Synonyms: VMRC-MELGKHM-1B: 12.68 (log10 µM)Synonyms: KHM-1B, KHM1BA431: 12.50 (log10 µM)Synonyms: A431, A-431EW-3: 11.78 (log10 µM)Synonyms: EW-3TASK1: 9.69 (log10 µM)Synonyms: TASK1A704: 9.43 (log10 µM)Synonyms: A704, A-704CRO-AP2: 9.42 (log10 µM)Synonyms: CRO-AP2KYSE-220: 9.42 (log10 µM)Synonyms: KYSE-220JURKAT: 9.37 (log10 µM)Synonyms: JURKAT, JurkatSNU-1041: 9.28 (log10 µM)Synonyms: SNU-1041, SNU1041OCUB-M: 9.22 (log10 µM)Synonyms: OCUB-M, ocubmKARPAS-422: 9.18 (log10 µM)Synonyms: KARPAS-422, KARPAS422NCI-H1155: 9.15 (log10 µM)Synonyms: NCI-H1155, NCIH1155NCI-H1703: 9.11 (log10 µM)Synonyms: NCI-H1703, NCIH1703HEC-1: 8.92 (log10 µM)Synonyms: HEC-1, HEC-1-BSK-MEL-31: 8.67 (log10 µM)Synonyms: SK-MEL-31, SKMEL31OSC-19: 8.17 (log10 µM)Synonyms: OSC-19IA-LM: 8.10 (log10 µM)Synonyms: IA-LM, IALMEW-16: 8.01 (log10 µM)Synonyms: EW-16Hs 683: 7.73 (log10 µM)Synonyms: Hs 683, Hs_683, Hs-683, Hs683, HS683CTB-1: 7.69 (log10 µM)Synonyms: CTB-1KNS-42: 7.68 (log10 µM)Synonyms: KNS-42, KNS42HEC-265: 7.48 (log10 µM)Synonyms: HEC-265, HEC265 : 0.00 (log10 µM)Synonyms: : 0.00 (log10 µM)Synonyms: : 0.00 (log10 µM)Synonyms: : 0.00 (log10 µM)Synonyms: : 0.00 (log10 µM)Synonyms: WM-88: -1.06 (log10 µM)Synonyms: WM-88, WM88DU-4475: -1.09 (log10 µM)Synonyms: DU-4475, DU4475, du4475HTC-C3: -1.10 (log10 µM)Synonyms: HTC-C3Malme-3M: -1.11 (log10 µM)Synonyms: Malme-3M, MALME3MKMOE-2: -1.13 (log10 µM)Synonyms: KMOE-2LB2518-MEL: -1.14 (log10 µM)Synonyms: LB2518-MELIPC-298: -1.20 (log10 µM)Synonyms: IPC-298, IPC298CP50-MEL-B: -1.20 (log10 µM)Synonyms: CP50-MEL-BMEL-HO: -1.21 (log10 µM)Synonyms: MEL-HO, MELHOJVM-2: -1.23 (log10 µM)Synonyms: JVM-2, JVM2UACC-62: -1.26 (log10 µM)Synonyms: UACC-62, UACC62NB4: -1.27 (log10 µM)Synonyms: NB4, NB-4SNU-620: -1.28 (log10 µM)Synonyms: SNU-620, SNU620OCUM-1: -1.33 (log10 µM)Synonyms: OCUM-1, OCUM1HuT 78: -1.39 (log10 µM)Synonyms: HuT 78, HuT_78, HUT78HCC2998: -1.39 (log10 µM)Synonyms: HCC2998NUGC-4: -1.40 (log10 µM)Synonyms: NUGC-4, NUGC4CL-34: -1.42 (log10 µM)Synonyms: CL-34, CL34YD-10B: -1.44 (log10 µM)Synonyms: YD-10B, YD10BM14: -1.45 (log10 µM)Synonyms: M14K5: -1.46 (log10 µM)Synonyms: K5OCI-AML3: -1.47 (log10 µM)Synonyms: OCI-AML3, OCIAML3NU-DUL-1: -1.47 (log10 µM)Synonyms: NU-DUL-1, NUDUL1K2: -1.53 (log10 µM)Synonyms: K2CHP-212: -1.60 (log10 µM)Synonyms: CHP-212, CHP212BB49-HNC: -1.61 (log10 µM)Synonyms: BB49-HNCSIG-M5: -1.62 (log10 µM)Synonyms: SIG-M5, SIGM5G-MEL: -1.69 (log10 µM)Synonyms: G-MELMMAC-SF: -1.73 (log10 µM)Synonyms: MMAC-SFOCI-AML2: -1.83 (log10 µM)Synonyms: OCI-AML2, OCIAML2AACpIC50* Plot represents the top and bottom 30 data points** Error Bars represent the Median Absolute Deviation
Download Data as CSV
AZD6244: AACAACTissues0.000.100.200.300.400.500.600.70small_intestinesmall_intestineotherotherplacentaplacentaneuroblastomaneuroblastomatestistestisprostateprostatecervixcervixbonebonepleurapleurabreastbreasthaematopoietic_and_lymphoid_tissuehaematopoietic_and_lymphoid_tissueoesophagusoesophaguslunglungcentral_nervous_systemcentral_nervous_systemhead_and_neckhead_and_necksoft_tissuesoft_tissueendometriumendometriumliverliverautonomic_gangliaautonomic_gangliakidneykidneyovaryovarystomachstomachoral_cavityoral_cavityurinary_tracturinary_tractunknownunknownbiliary_tractbiliary_tractupper_aerodigestive_tractupper_aerodigestive_tractadrenal_glandadrenal_glandpancreaspancreasskinskinlarge_intestinelarge_intestinethyroidthyroidvulvavulvasalivary_glandsalivary_glandmiscmisc-1.000.001.002.003.004.005.006.007.008.009.00miscmiscskinskinboneboneautonomic_gangliaautonomic_gangliaplacentaplacentaneuroblastomaneuroblastomasalivary_glandsalivary_glandthyroidthyroidvulvavulvaadrenal_glandadrenal_glandbreastbreastlarge_intestinelarge_intestinehaematopoietic_and_lymphoid_tissuehaematopoietic_and_lymphoid_tissuetestistestisprostateprostatesmall_intestinesmall_intestinehead_and_neckhead_and_neckurinary_tracturinary_tractpancreaspancreascervixcervixoesophagusoesophaguslunglungovaryovaryupper_aerodigestive_tractupper_aerodigestive_tractbiliary_tractbiliary_tractotherotherliverliverkidneykidneypleurapleurastomachstomachsoft_tissuesoft_tissuecentral_nervous_systemcentral_nervous_systemendometriumendometriumunknownunknownoral_cavityoral_cavityAACpIC50= Truncated outliers