PharmacoDB

Sources

Names Used

Irinotecan

irinotecan

CPT-11

PharmacoGx

Irinotecan

Database	Identifier
Smiles:	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
Inchikey:	UWKQSNNFCGGAFS-XIFFEERXSA-N
Pubchem:	60838

Database

Identifier

Smiles:

CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7

Inchikey:

UWKQSNNFCGGAFS-XIFFEERXSA-N

Pubchem:

Top molecular features associated with response to Irinotecan

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	THAP11	CCLE	pan-cancer	AAC	0.17	0.002
mRNA	B4GALT3	gCSI	pan-cancer	AAC	-0.17	0.002
mRNA	TMEM132D	gCSI	pan-cancer	AAC	-0.16	0.002
mRNA	LMCD1	gCSI	pan-cancer	AAC	-0.19	0.002
mRNA	GPN1	CCLE	pan-cancer	AAC	0.17	0.002
mRNA	TNFRSF10D	gCSI	pan-cancer	AAC	0.18	0.002
mRNA	UTP6	CCLE	pan-cancer	AAC	0.17	0.002
mRNA	SPATA5L1	CCLE	pan-cancer	AAC	0.17	0.002
mRNA	CST4	gCSI	pan-cancer	AAC	-0.17	0.002
mRNA	CARNS1	gCSI	pan-cancer	AAC	-0.16	0.002