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lapatinib

Synonyms

SourcesNames Used
CCLE, GDSC1000, GRAY, FIMM, UHNBreastLapatinib
gCSI, CTRPv2lapatinib
PharmacoGx lapatinib

External IDs

DatabaseIdentifier
Smiles: CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
Inchikey: BCFGMOOMADDAQU-UHFFFAOYSA-N
Pubchem: 208908

Annotated Targets

ERBB2, EGFR

FDA Approval Status

Approved
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Top molecular features associated with response to lapatinib


Feature TypeStandardized
Nominal ANOVA
mRNA B4GALNT2 CTRPv2 pan-cancer AAC 0.13 0.0002
mRNA ZNF185 CCLE pan-cancer AAC 0.2 0.0002
mRNA TRPM4 gCSI pan-cancer AAC 0.23 0.0002
mRNA PSCA GDSC1000 pan-cancer AAC 0.18 0.0002
mRNA SERPINB3 CCLE pan-cancer AAC 0.16 0.0002
mRNA C16orf74 gCSI pan-cancer AAC 0.21 0.0002
mRNA TJP3 CTRPv2 pan-cancer AAC 0.15 0.0002
mRNA WNT5B CCLE pan-cancer AAC -0.17 0.0002
mRNA VKORC1 CTRPv2 pan-cancer AAC -0.15 0.0002
mRNA SERPINB5 CTRPv2 pan-cancer AAC 0.15 0.0002
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