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paclitaxel

Synonyms

SourcesNames Used
CCLE, GDSC1000, GRAY, FIMM, UHNBreastPaclitaxel
gCSI, CTRPv2paclitaxel
PharmacoGx paclitaxel

External IDs

DatabaseIdentifier
Smiles: CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]4[C@@]5(CO[C@@H]5C[C@H](O)[C@@]4(C)C1=O)OC(=O)C)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c6ccccc6)c7ccccc7
Inchikey: RCINICONZNJXQF-MZXODVADSA-N
Pubchem: 36314

Annotated Targets

BCL2, MAP2, MAP4, MAPT, NR1I2, TLR4, TUBB, TUBB1

FDA Approval Status

Approved
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Top molecular features associated with response to paclitaxel


Feature TypeStandardized
Nominal ANOVA
mRNA RIOK1 gCSI pan-cancer AAC 0.21 0.0002
mRNA SLC2A11 gCSI pan-cancer AAC -0.2 0.0002
mRNA FRY gCSI pan-cancer AAC -0.19 0.0002
mRNA CECR2 CTRPv2 pan-cancer AAC 0.12 0.0002
mRNA FBRSL1 CTRPv2 pan-cancer AAC 0.13 0.0002
mRNA GABPB1 CCLE pan-cancer AAC 0.2 0.0002
mRNA TMA16 CTRPv2 pan-cancer AAC 0.13 0.0002
mRNA DLGAP3 UHNBreast pan-cancer AAC -0.88 0.0002
mRNA KIF11 CTRPv2 pan-cancer AAC 0.12 0.0002
mRNA CSTF2 CCLE pan-cancer AAC 0.17 0.0002
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