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paclitaxel

Synonyms

SourcesNames Used
CCLE, GDSC1000, GRAY, FIMM, UHNBreastPaclitaxel
gCSI, CTRPv2paclitaxel
PharmacoGx paclitaxel

External IDs

DatabaseIdentifier
Smiles: CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]4[C@@]5(CO[C@@H]5C[C@H](O)[C@@]4(C)C1=O)OC(=O)C)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c6ccccc6)c7ccccc7
Inchikey: RCINICONZNJXQF-MZXODVADSA-N
Pubchem: 36314

Annotated Targets

BCL2, MAP2, MAP4, MAPT, NR1I2, TLR4, TUBB, TUBB1

FDA Approval Status

Approved
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Top molecular features associated with response to paclitaxel


Feature TypeStandardized
Nominal ANOVA
mRNA MSL1 CTRPv2 pan-cancer AAC 0.12 0.0002
mRNA KDM1A CCLE pan-cancer AAC 0.17 0.0002
mRNA ME2 gCSI pan-cancer AAC 0.23 0.0002
mRNA MRPL35 CCLE pan-cancer AAC 0.17 0.0002
mRNA MAST3 CCLE pan-cancer AAC 0.19 0.0002
mRNA MAP4K3 CCLE pan-cancer AAC -0.2 0.0002
mRNA DCLRE1A CCLE pan-cancer AAC 0.17 0.0002
mRNA TNFRSF1A CTRPv2 pan-cancer AAC -0.13 0.0002
mRNA VRK1 CTRPv2 pan-cancer AAC 0.14 0.0002
mRNA PCGF6 gCSI pan-cancer AAC 0.19 0.0002
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