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Topotecan

Synonyms

SourcesNames Used
CCLE, GRAY, FIMMTopotecan
CTRPv2topotecan
PharmacoGx Topotecan

External IDs

DatabaseIdentifier
Smiles: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)[NH+]=C5C=CC(=C(C5=C4)CN(C)C)O)O.[Cl-]
Inchikey: DGHHQBMTXTWTJV-BQAIUKQQSA-N
Pubchem: 11972519

Annotated Targets

TOP1MT, TOP1

FDA Approval Status

Approved
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Top molecular features associated with response to Topotecan


Feature TypeStandardized
Nominal ANOVA
mRNA ADD2 CCLE pan-cancer AAC 0.16 0.0001
mRNA CDK13 CTRPv2 pan-cancer AAC 0.12 0.0001
mRNA TTK CCLE pan-cancer AAC 0.16 0.0001
mRNA HIST1H2BC CCLE pan-cancer AAC -0.16 0.0001
mRNA PBRM1 CCLE pan-cancer AAC 0.19 0.0001
mRNA BLVRB CCLE pan-cancer AAC -0.18 0.0001
mRNA SPIDR CCLE pan-cancer AAC 0.17 0.0001
mRNA AMER2 CTRPv2 pan-cancer AAC 0.13 0.0001
mRNA LEMD3 CTRPv2 pan-cancer AAC 0.12 0.0001
mRNA CLIC5 CCLE pan-cancer AAC -0.17 0.0001
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