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Topotecan

Synonyms

SourcesNames Used
CCLE, GRAY, FIMMTopotecan
CTRPv2topotecan
PharmacoGx Topotecan

External IDs

DatabaseIdentifier
Smiles: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)[NH+]=C5C=CC(=C(C5=C4)CN(C)C)O)O.[Cl-]
Inchikey: DGHHQBMTXTWTJV-BQAIUKQQSA-N
Pubchem: 11972519

Annotated Targets

TOP1MT, TOP1

FDA Approval Status

Approved
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Top molecular features associated with response to Topotecan


Feature TypeStandardized
Nominal ANOVA
mRNA ATP6V0E1 CCLE pan-cancer AAC -0.27 6e-09
mRNA KIF11 CCLE pan-cancer AAC 0.24 6e-09
mRNA SOX4 CTRPv2 pan-cancer AAC 0.18 6e-09
mRNA GPHN CTRPv2 pan-cancer AAC 0.19 6e-09
mRNA SRP9 CTRPv2 pan-cancer AAC 0.19 6e-09
mRNA WTAP CTRPv2 pan-cancer AAC 0.18 7e-09
mRNA ING5 CTRPv2 pan-cancer AAC 0.2 7e-09
mRNA DNA2 CCLE pan-cancer AAC 0.26 8e-09
mRNA TMED7-TICAM2 CTRPv2 pan-cancer AAC -0.21 8e-09
mRNA ILF3 CCLE pan-cancer AAC 0.26 8e-09
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