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Topotecan

Synonyms

SourcesNames Used
CCLE, GRAY, FIMMTopotecan
CTRPv2topotecan
PharmacoGx Topotecan

External IDs

DatabaseIdentifier
Smiles: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)[NH+]=C5C=CC(=C(C5=C4)CN(C)C)O)O.[Cl-]
Inchikey: DGHHQBMTXTWTJV-BQAIUKQQSA-N
Pubchem: 11972519

Annotated Targets

TOP1MT, TOP1

FDA Approval Status

Approved
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Top molecular features associated with response to Topotecan


Feature TypeStandardized
Nominal ANOVA
mRNA ZNF428 CTRPv2 pan-cancer AAC 0.18 5e-08
mRNA PHF14 CTRPv2 pan-cancer AAC 0.18 5e-08
mRNA FUBP1 CTRPv2 pan-cancer AAC 0.18 5e-08
mRNA RFX3 CTRPv2 pan-cancer AAC 0.18 5e-08
mRNA HACE1 CTRPv2 pan-cancer AAC 0.17 6e-08
mRNA KNTC1 CTRPv2 pan-cancer AAC 0.18 6e-08
mRNA RNF138 CCLE pan-cancer AAC 0.25 6e-08
mRNA TRA2B CTRPv2 pan-cancer AAC 0.18 6e-08
mRNA ARID1A CTRPv2 pan-cancer AAC 0.19 6e-08
mRNA NFYB CCLE pan-cancer AAC 0.24 6e-08
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