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Topotecan

Synonyms

SourcesNames Used
CCLE, GRAY, FIMMTopotecan
CTRPv2topotecan
PharmacoGx Topotecan

External IDs

DatabaseIdentifier
Smiles: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)[NH+]=C5C=CC(=C(C5=C4)CN(C)C)O)O.[Cl-]
Inchikey: DGHHQBMTXTWTJV-BQAIUKQQSA-N
Pubchem: 11972519

Annotated Targets

TOP1MT, TOP1

FDA Approval Status

Approved
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Top molecular features associated with response to Topotecan


Feature TypeStandardized
Nominal ANOVA
mRNA SLC38A6 CTRPv2 pan-cancer AAC -0.13 0.0001
mRNA CNOT10 CTRPv2 pan-cancer AAC 0.14 0.0001
mRNA CENPC CTRPv2 pan-cancer AAC 0.14 0.0001
mRNA DOT1L CCLE pan-cancer AAC 0.19 0.0001
mRNA PM20D2 CCLE pan-cancer AAC 0.18 0.0001
mRNA GRN CCLE pan-cancer AAC -0.16 0.0001
mRNA WFS1 CCLE pan-cancer AAC -0.19 0.0001
mRNA AHCTF1 CTRPv2 pan-cancer AAC 0.12 0.0001
mRNA BLVRB CTRPv2 pan-cancer AAC -0.12 0.0001
mRNA SLC12A4 CTRPv2 pan-cancer AAC -0.13 0.0001
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