PharmacoDB

Sources

Names Used

Topotecan

topotecan

PharmacoGx

Topotecan

Database	Identifier
Smiles:	CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)[NH+]=C5C=CC(=C(C5=C4)CN(C)C)O)O.[Cl-]
Inchikey:	DGHHQBMTXTWTJV-BQAIUKQQSA-N
Pubchem:	11972519

Database

Identifier

Smiles:

CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)[NH+]=C5C=CC(=C(C5=C4)CN(C)C)O)O.[Cl-]

Inchikey:

DGHHQBMTXTWTJV-BQAIUKQQSA-N

Pubchem:

Top molecular features associated with response to Topotecan

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	MCM6	CCLE	pan-cancer	AAC	0.28	3e-09
mRNA	ITGB5	CTRPv2	pan-cancer	AAC	-0.22	3e-09
mRNA	CCNF	CTRPv2	pan-cancer	AAC	0.2	3e-09
mRNA	ZNF253	CTRPv2	pan-cancer	AAC	0.2	3e-09
mRNA	KNTC1	CCLE	pan-cancer	AAC	0.26	4e-09
mRNA	ZNF292	CTRPv2	pan-cancer	AAC	0.2	4e-09
mRNA	PIDD1	CTRPv2	pan-cancer	AAC	0.19	4e-09
mRNA	CPSF6	CCLE	pan-cancer	AAC	0.3	4e-09
mRNA	PTMA	CTRPv2	pan-cancer	AAC	0.22	4e-09
mRNA	PTBP1	CCLE	pan-cancer	AAC	0.25	4e-09