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Irinotecan

Synonyms

SourcesNames Used
CCLE, FIMMIrinotecan
gCSIirinotecan
GRAYCPT-11
PharmacoGx Irinotecan

External IDs

DatabaseIdentifier
Smiles: CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
Inchikey: UWKQSNNFCGGAFS-XIFFEERXSA-N
Pubchem: 60838

Annotated Targets

TOP1, TOP1MT

FDA Approval Status

Approved
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Top molecular features associated with response to Irinotecan


Feature TypeStandardized
Nominal ANOVA
mRNA RRAS CCLE pan-cancer AAC -0.22 0.001
mRNA HEXA gCSI pan-cancer AAC -0.17 0.001
mRNA EEF1B2 gCSI pan-cancer AAC 0.19 0.001
mRNA NAF1 CCLE pan-cancer AAC 0.17 0.001
mRNA TRIM22 gCSI pan-cancer AAC 0.18 0.001
mRNA CNOT1 CCLE pan-cancer AAC 0.19 0.001
mRNA PFN1 gCSI pan-cancer AAC 0.18 0.001
mRNA NCL gCSI pan-cancer AAC 0.16 0.001
mRNA TPRG1 gCSI pan-cancer AAC -0.18 0.001
mRNA NCBP2 CCLE pan-cancer AAC 0.17 0.001
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