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Irinotecan

Synonyms

SourcesNames Used
CCLE, FIMMIrinotecan
gCSIirinotecan
GRAYCPT-11
PharmacoGx Irinotecan

External IDs

DatabaseIdentifier
Smiles: CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
Inchikey: UWKQSNNFCGGAFS-XIFFEERXSA-N
Pubchem: 60838

Annotated Targets

TOP1, TOP1MT

FDA Approval Status

Approved
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Top molecular features associated with response to Irinotecan


Feature TypeStandardized
Nominal ANOVA
mRNA GOLGA5 CCLE pan-cancer AAC -0.26 5e-06
mRNA NCAPG CCLE pan-cancer AAC 0.24 5e-06
mRNA PLD3 gCSI pan-cancer AAC -0.24 5e-06
mRNA DEPTOR CCLE pan-cancer AAC -0.25 6e-06
mRNA MAGOH CCLE pan-cancer AAC 0.25 6e-06
mRNA PPIA CCLE pan-cancer AAC 0.24 6e-06
mRNA FBXO5 gCSI pan-cancer AAC 0.24 6e-06
mRNA USP1 CCLE pan-cancer AAC 0.24 6e-06
mRNA HTR2C gCSI pan-cancer AAC -0.23 6e-06
mRNA BPTF CCLE pan-cancer AAC 0.26 6e-06
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