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Irinotecan

Synonyms

SourcesNames Used
CCLE, FIMMIrinotecan
gCSIirinotecan
GRAYCPT-11
PharmacoGx Irinotecan

External IDs

DatabaseIdentifier
Smiles: CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
Inchikey: UWKQSNNFCGGAFS-XIFFEERXSA-N
Pubchem: 60838

Annotated Targets

TOP1, TOP1MT

FDA Approval Status

Approved
Dataset Select
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Top molecular features associated with response to Irinotecan


Feature TypeStandardized
Nominal ANOVA
mRNA PPP1CC gCSI pan-cancer AAC 0.25 3e-06
mRNA ANP32B CCLE pan-cancer AAC 0.28 3e-06
mRNA RORA gCSI pan-cancer AAC -0.24 3e-06
mRNA TMBIM1 CCLE pan-cancer AAC -0.29 3e-06
mRNA CCNA2 CCLE pan-cancer AAC 0.25 3e-06
mRNA GSG2 gCSI pan-cancer AAC 0.25 3e-06
mRNA EXOSC9 gCSI pan-cancer AAC 0.26 3e-06
mRNA SUPT16H gCSI pan-cancer AAC 0.24 3e-06
mRNA EXOSC3 gCSI pan-cancer AAC 0.23 3e-06
mRNA CDC40 gCSI pan-cancer AAC 0.25 3e-06
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