PharmacoDB

Sources

Names Used

Irinotecan

irinotecan

CPT-11

PharmacoGx

Irinotecan

Database	Identifier
Smiles:	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
Inchikey:	UWKQSNNFCGGAFS-XIFFEERXSA-N
Pubchem:	60838

Database

Identifier

Smiles:

CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7

Inchikey:

UWKQSNNFCGGAFS-XIFFEERXSA-N

Pubchem:

Top molecular features associated with response to Irinotecan

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	C12orf29	CCLE	pan-cancer	AAC	0.26	2e-06
mRNA	SLC2A11	gCSI	pan-cancer	AAC	-0.26	2e-06
mRNA	TPP1	CCLE	pan-cancer	AAC	-0.26	2e-06
mRNA	NUDT15	CCLE	pan-cancer	AAC	0.27	2e-06
mRNA	RPS6	gCSI	pan-cancer	AAC	0.28	2e-06
mRNA	RRM1	CCLE	pan-cancer	AAC	0.25	2e-06
mRNA	POLE	CCLE	pan-cancer	AAC	0.26	2e-06
mRNA	RRM2	CCLE	pan-cancer	AAC	0.24	2e-06
mRNA	CCT2	CCLE	pan-cancer	AAC	0.25	2e-06
mRNA	EXOSC2	CCLE	pan-cancer	AAC	0.25	2e-06