PharmacoDB

Sources

Names Used

Irinotecan

irinotecan

CPT-11

PharmacoGx

Irinotecan

Database	Identifier
Smiles:	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
Inchikey:	UWKQSNNFCGGAFS-XIFFEERXSA-N
Pubchem:	60838

Database

Identifier

Smiles:

CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7

Inchikey:

UWKQSNNFCGGAFS-XIFFEERXSA-N

Pubchem:

Top molecular features associated with response to Irinotecan

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ESPL1	CCLE	pan-cancer	AAC	0.23	3e-05
mRNA	OR8D4	gCSI	pan-cancer	AAC	0.2	3e-05
mRNA	ACTR2	gCSI	pan-cancer	AAC	0.23	3e-05
mRNA	PSIP1	CCLE	pan-cancer	AAC	0.24	3e-05
mRNA	RPL26	gCSI	pan-cancer	AAC	0.22	3e-05
mRNA	IKBKAP	CCLE	pan-cancer	AAC	0.22	3e-05
mRNA	LSM6	gCSI	pan-cancer	AAC	0.22	3e-05
mRNA	NUPR1	CCLE	pan-cancer	AAC	-0.26	3e-05
mRNA	CDCA8	CCLE	pan-cancer	AAC	0.22	3e-05
mRNA	EZH2	CCLE	pan-cancer	AAC	0.24	3e-05