PharmacoDB

Sources

Names Used

Irinotecan

irinotecan

CPT-11

PharmacoGx

Irinotecan

Database	Identifier
Smiles:	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
Inchikey:	UWKQSNNFCGGAFS-XIFFEERXSA-N
Pubchem:	60838

Database

Identifier

Smiles:

CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7

Inchikey:

UWKQSNNFCGGAFS-XIFFEERXSA-N

Pubchem:

Top molecular features associated with response to Irinotecan

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	HIST1H2BN	gCSI	pan-cancer	AAC	-0.22	2e-05
mRNA	FUK	gCSI	pan-cancer	AAC	-0.22	2e-05
mRNA	CHAF1A	CCLE	pan-cancer	AAC	0.23	2e-05
mRNA	CNTRL	CCLE	pan-cancer	AAC	0.32	2e-05
mRNA	NRBP2	CCLE	pan-cancer	AAC	-0.26	2e-05
mRNA	POLR1E	CCLE	pan-cancer	AAC	0.22	2e-05
mRNA	MZT1	gCSI	pan-cancer	AAC	0.22	3e-05
mRNA	GOLGA1	gCSI	pan-cancer	AAC	-0.24	3e-05
mRNA	GLB1	CCLE	pan-cancer	AAC	-0.23	3e-05
mRNA	METAP2	gCSI	pan-cancer	AAC	0.22	3e-05