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Irinotecan

Synonyms

SourcesNames Used
CCLE, FIMMIrinotecan
gCSIirinotecan
GRAYCPT-11
PharmacoGx Irinotecan

External IDs

DatabaseIdentifier
Smiles: CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
Inchikey: UWKQSNNFCGGAFS-XIFFEERXSA-N
Pubchem: 60838

Annotated Targets

TOP1, TOP1MT

FDA Approval Status

Approved
Dataset Select
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Top molecular features associated with response to Irinotecan


Feature TypeStandardized
Nominal ANOVA
mRNA RPL22L1 gCSI pan-cancer AAC 0.29 2e-08
mRNA NOL11 CCLE pan-cancer AAC 0.29 2e-08
mRNA UHRF1 gCSI pan-cancer AAC 0.3 3e-08
mRNA SSRP1 CCLE pan-cancer AAC 0.29 3e-08
mRNA SNRPF CCLE pan-cancer AAC 0.28 4e-08
mRNA ATP6V0E1 CCLE pan-cancer AAC -0.31 5e-08
mRNA HMGB2 CCLE pan-cancer AAC 0.34 5e-08
mRNA NRF1 CCLE pan-cancer AAC 0.33 5e-08
mRNA WDR5 CCLE pan-cancer AAC 0.29 5e-08
mRNA DAZAP1 gCSI pan-cancer AAC 0.31 6e-08
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