PharmacoDB

Sources

Names Used

Irinotecan

irinotecan

CPT-11

PharmacoGx

Irinotecan

Database	Identifier
Smiles:	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
Inchikey:	UWKQSNNFCGGAFS-XIFFEERXSA-N
Pubchem:	60838

Database

Identifier

Smiles:

CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7

Inchikey:

UWKQSNNFCGGAFS-XIFFEERXSA-N

Pubchem:

Top molecular features associated with response to Irinotecan

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	OTOGL	gCSI	pan-cancer	AAC	-0.22	1e-05
mRNA	HM13	gCSI	pan-cancer	AAC	-0.24	1e-05
mRNA	SRSF3	CCLE	pan-cancer	AAC	0.24	1e-05
mRNA	LGALS3	CCLE	pan-cancer	AAC	-0.27	1e-05
mRNA	FASTK	gCSI	pan-cancer	AAC	-0.25	1e-05
mRNA	SLC39A7	gCSI	pan-cancer	AAC	-0.26	1e-05
mRNA	CHAF1B	CCLE	pan-cancer	AAC	0.23	1e-05
mRNA	POLR1E	gCSI	pan-cancer	AAC	0.22	1e-05
mRNA	LYAR	CCLE	pan-cancer	AAC	0.24	1e-05
mRNA	HIST1H1C	gCSI	pan-cancer	AAC	-0.22	1e-05