PharmacoDB

Sources

Names Used

Irinotecan

irinotecan

CPT-11

PharmacoGx

Irinotecan

Database	Identifier
Smiles:	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
Inchikey:	UWKQSNNFCGGAFS-XIFFEERXSA-N
Pubchem:	60838

Database

Identifier

Smiles:

CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7

Inchikey:

UWKQSNNFCGGAFS-XIFFEERXSA-N

Pubchem:

Top molecular features associated with response to Irinotecan

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	SERBP1	CCLE	pan-cancer	AAC	0.25	9e-06
mRNA	ZNF143	CCLE	pan-cancer	AAC	0.24	9e-06
mRNA	MRPL42	gCSI	pan-cancer	AAC	0.23	9e-06
mRNA	PLA2G6	gCSI	pan-cancer	AAC	-0.25	9e-06
mRNA	TAF5	gCSI	pan-cancer	AAC	0.24	9e-06
mRNA	RILPL2	gCSI	pan-cancer	AAC	0.24	9e-06
mRNA	HDAC2	gCSI	pan-cancer	AAC	0.23	1e-05
mRNA	NUDT21	CCLE	pan-cancer	AAC	0.24	1e-05
mRNA	SKA3	CCLE	pan-cancer	AAC	0.23	1e-05
mRNA	KIF2C	CCLE	pan-cancer	AAC	0.23	1e-05