PharmacoDB

Sources

Names Used

Irinotecan

irinotecan

CPT-11

PharmacoGx

Irinotecan

Database	Identifier
Smiles:	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
Inchikey:	UWKQSNNFCGGAFS-XIFFEERXSA-N
Pubchem:	60838

Database

Identifier

Smiles:

CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7

Inchikey:

UWKQSNNFCGGAFS-XIFFEERXSA-N

Pubchem:

Top molecular features associated with response to Irinotecan

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	DIMT1	gCSI	pan-cancer	AAC	0.24	6e-06
mRNA	SEMA5A	CCLE	pan-cancer	AAC	-0.29	6e-06
mRNA	BAX	gCSI	pan-cancer	AAC	0.25	6e-06
mRNA	DEPTOR	gCSI	pan-cancer	AAC	-0.27	6e-06
mRNA	PPIC	CCLE	pan-cancer	AAC	-0.37	6e-06
mRNA	CATSPERG	gCSI	pan-cancer	AAC	-0.24	6e-06
mRNA	OR56A5	gCSI	pan-cancer	AAC	-0.23	6e-06
mRNA	TNS3	CCLE	pan-cancer	AAC	-0.25	6e-06
mRNA	PLK4	CCLE	pan-cancer	AAC	0.24	6e-06
mRNA	CEP104	gCSI	pan-cancer	AAC	-0.23	6e-06