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Irinotecan

Synonyms

SourcesNames Used
CCLE, FIMMIrinotecan
gCSIirinotecan
GRAYCPT-11
PharmacoGx Irinotecan

External IDs

DatabaseIdentifier
Smiles: CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
Inchikey: UWKQSNNFCGGAFS-XIFFEERXSA-N
Pubchem: 60838

Annotated Targets

TOP1, TOP1MT

FDA Approval Status

Approved
Dataset Select
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Top molecular features associated with response to Irinotecan


Feature TypeStandardized
Nominal ANOVA
mRNA ANKRD30A gCSI pan-cancer AAC -0.25 1e-06
mRNA METAP2 CCLE pan-cancer AAC 0.26 1e-06
mRNA MPHOSPH9 CCLE pan-cancer AAC 0.26 2e-06
mRNA CTSA CCLE pan-cancer AAC -0.29 2e-06
mRNA DNA2 CCLE pan-cancer AAC 0.28 2e-06
mRNA TM9SF4 gCSI pan-cancer AAC -0.26 2e-06
mRNA SNRPD1 CCLE pan-cancer AAC 0.26 2e-06
mRNA SLC5A2 gCSI pan-cancer AAC -0.24 2e-06
mRNA TMEM184B gCSI pan-cancer AAC -0.28 2e-06
mRNA SQSTM1 gCSI pan-cancer AAC -0.28 2e-06
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