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Sorafenib

Synonyms

SourcesNames Used
CCLE, GDSC1000, GRAY, FIMMSorafenib
CTRPv2sorafenib
PharmacoGx Sorafenib

External IDs

DatabaseIdentifier
Smiles: CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
Inchikey: MLDQJTXFUGDVEO-UHFFFAOYSA-N
Pubchem: 216239

Annotated Targets

BRAF, KIT, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, PDGFRB, RAF1, RET

FDA Approval Status

Approved
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Top molecular features associated with response to Sorafenib


Feature TypeStandardized
Nominal ANOVA
mRNA ELANE CCLE pan-cancer AAC 0.39 2e-18
mRNA RNASE3 CCLE pan-cancer AAC 0.39 5e-18
mRNA DPEP3 CCLE pan-cancer AAC 0.38 5e-18
mRNA OCSTAMP GDSC1000 pan-cancer AAC 0.44 6e-18
mRNA DPEP2 CCLE pan-cancer AAC 0.42 1e-17
mRNA FLT3 CCLE pan-cancer AAC 0.38 2e-17
mRNA CSF3R CCLE pan-cancer AAC 0.37 1e-16
mRNA TIFAB GDSC1000 pan-cancer AAC 0.41 1e-16
mRNA STAR CCLE pan-cancer AAC 0.38 2e-16
mRNA CTSG CCLE pan-cancer AAC 0.38 2e-16
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