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GDC-0941

Synonyms

SourcesNames Used
GDSC1000GDC0941
gCSIgdc0941
FIMMPictilisib
CTRPv2GDC-0941
PharmacoGx GDC-0941

External IDs

DatabaseIdentifier
Smiles: CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6
Inchikey: LHNIIDJUOCFXAP-UHFFFAOYSA-N
Pubchem: 17755052

Annotated Targets

PIK3CA, PIK3CB, PIK3CD, PIK3CG

FDA Approval Status

Not Approved
Number of cell lines tested with GDC-0941(per dataset)0100200300400500600700800900# cell lines CCLEGRAYUHNBreastFIMMgCSICTRPv2GDSC100000050400856997
Number of tissues tested with GDC-0941(per dataset)05101520253035# tissues CCLEGRAYUHNBreastFIMMgCSICTRPv2GDSC10000004232535
Dataset Select
GDC-0941: AACAAC0.000.100.200.300.400.500.600.70OCI-LY-7OCI-LY-7RI-1RI-1SU-DHL-6SU-DHL-6NCI-H929NCI-H929KASUMI-2KASUMI-2SNU-216SNU-216DOKDOKMM1-SMM1-SHAL-01HAL-01YD-10BYD-10BMOLM-16MOLM-16U-BLC1U-BLC1HHHHRPMI-8866RPMI-8866WSU-NHLWSU-NHLPfeifferPfeifferSU-DHL-5SU-DHL-5CAL-33CAL-33KMS-20KMS-20SK-ES-1SK-ES-120042004YAMATOYAMATONU-DUL-1NU-DUL-1GA-10GA-10A4-FukA4-FukTM87-16TM87-16RCH-ACVRCH-ACVES5ES5KMS-34KMS-34BT239BT239 MRK-nu-1MRK-nu-1KP-N-YNKP-N-YNM14M14NCI-SNU-1NCI-SNU-1NCI-H2087NCI-H2087COLO-783COLO-783COR-L321COR-L321NB13NB13SHP-77SHP-77BT12BT12NCI-H810NCI-H810NCI-H146NCI-H146KM12KM12ToledoToledoME-1ME-1MC-IXCMC-IXCT3M-10T3M-10ROS-50ROS-50PSTSPSTSPCI-15APCI-15ASCC-3SCC-3HCC2998HCC2998BENBENNCI-H2135NCI-H2135NB(TU)1-10NB(TU)1-10A253A253AM-38AM-38HCC1428HCC1428KM-H2KM-H2NB17NB17OCI-LY-7RI-1SU-DHL-6NCI-H929KASUMI-2SNU-216DOKMM1-SHAL-01YD-10BMOLM-16U-BLC1HHRPMI-8866WSU-NHLPfeifferSU-DHL-5CAL-33KMS-20SK-ES-12004YAMATONU-DUL-1GA-10A4-FukTM87-16RCH-ACVES5KMS-34BT239 MRK-nu-1KP-N-YNM14NCI-SNU-1NCI-H2087COLO-783COR-L321NB13SHP-77BT12NCI-H810NCI-H146KM12ToledoME-1MC-IXCT3M-10ROS-50PSTSPCI-15ASCC-3HCC2998BENNCI-H2135NB(TU)1-10A253AM-38HCC1428KM-H2NB17OCI-LY-7: 0.74Synonyms: OCI-LY-7, OCI-LY7RI-1: 0.74Synonyms: RI-1, RI1SU-DHL-6: 0.65Synonyms: SU-DHL-6, SUDHL6NCI-H929: 0.58Synonyms: NCI-H929, NCIH929KASUMI-2: 0.57Synonyms: KASUMI-2, KASUMI2SNU-216: 0.56Synonyms: SNU-216, SNU216DOK: 0.56Synonyms: DOKMM1-S: 0.54Synonyms: MM1-S, MM1S, MM.1SHAL-01: 0.53Synonyms: HAL-01YD-10B: 0.53Synonyms: YD-10B, YD10BMOLM-16: 0.53Synonyms: MOLM-16, MOLM16U-BLC1: 0.51Synonyms: U-BLC1, UBLC1HH: 0.51Synonyms: HHRPMI-8866: 0.51Synonyms: RPMI-8866WSU-NHL: 0.51Synonyms: WSU-NHLPfeiffer: 0.50Synonyms: Pfeiffer, PFEIFFERSU-DHL-5: 0.49Synonyms: SU-DHL-5CAL-33: 0.49Synonyms: CAL-33, CAL33KMS-20: 0.49Synonyms: KMS-20, KMS20SK-ES-1: 0.49Synonyms: SK-ES-1, SKES12004: 0.47Synonyms: 2004YAMATO: 0.47Synonyms: YAMATONU-DUL-1: 0.47Synonyms: NU-DUL-1, NUDUL1GA-10: 0.47Synonyms: GA-10, GA10A4-Fuk: 0.46Synonyms: A4-Fuk, A4/Fuk, A4_Fuk, A4FUKTM87-16: 0.46Synonyms: TM87-16RCH-ACV: 0.46Synonyms: RCH-ACV, RCHACVES5: 0.46Synonyms: ES5KMS-34: 0.45Synonyms: KMS-34, KMS34BT239: 0.45Synonyms: BT239 : 0.00Synonyms: : 0.00Synonyms: : 0.00Synonyms: : 0.00Synonyms: : 0.00Synonyms: MRK-nu-1: 0.03Synonyms: MRK-nu-1KP-N-YN: 0.03Synonyms: KP-N-YN, KPNYNM14: 0.03Synonyms: M14NCI-SNU-1: 0.03Synonyms: NCI-SNU-1, SNU-1NCI-H2087: 0.03Synonyms: NCI-H2087, NCIH2087COLO-783: 0.03Synonyms: COLO-783COR-L321: 0.03Synonyms: COR-L321NB13: 0.03Synonyms: NB13SHP-77: 0.03Synonyms: SHP-77, SHP77BT12: 0.03Synonyms: BT12NCI-H810: 0.03Synonyms: NCI-H810, NCIH810NCI-H146: 0.02Synonyms: NCI-H146, NCIH146KM12: 0.02Synonyms: KM12, KM-12Toledo: 0.02Synonyms: Toledo, TOLEDOME-1: 0.02Synonyms: ME-1, ME1MC-IXC: 0.02Synonyms: MC-IXCT3M-10: 0.02Synonyms: T3M-10, T3M10ROS-50: 0.01Synonyms: ROS-50PSTS: 0.01Synonyms: PSTSPCI-15A: 0.01Synonyms: PCI-15ASCC-3: 0.01Synonyms: SCC-3HCC2998: 0.01Synonyms: HCC2998BEN: 0.01Synonyms: BENNCI-H2135: 0.01Synonyms: NCI-H2135NB(TU)1-10: 0.01Synonyms: NB(TU)1-10A253: 0.01Synonyms: A253, A-253AM-38: 0.01Synonyms: AM-38, AM38HCC1428: 0.01Synonyms: HCC1428, hcc1428KM-H2: 0.00Synonyms: KM-H2, KMH2NB17: 0.00Synonyms: NB17-1.000.001.002.003.004.005.006.007.008.009.0010.00HCC1428HCC1428MDA-MB-157MDA-MB-157CTB-1CTB-1LC4-1LC4-1JL-1JL-1SNU-869SNU-869ROS-50ROS-50OVSAHOOVSAHOTUHR14TKBTUHR14TKBNCI-H1688NCI-H1688NCI-H524NCI-H524HCC-1195HCC-1195SNU-398SNU-398COR-L321COR-L321DJM-1DJM-1BT498BT498COR-L88COR-L88LIM1215LIM1215VMRC-LCDVMRC-LCDHS578BSTHS578BSTTUHR4TKBTUHR4TKBNCI-H322MNCI-H322MLAMA-84LAMA-84JEG-3JEG-3L-428L-428RF-48RF-48EFE-184EFE-184SK-MEL-31SK-MEL-31SNU-489SNU-489MC-IXCMC-IXC MOLM-16MOLM-16SNU-216SNU-216DOKDOKYAMATOYAMATOES5ES5MHH-PREB-1MHH-PREB-1RCH-ACVRCH-ACVH3118H3118KARPAS-1106PKARPAS-1106PMOLT-4MOLT-4MEC-1MEC-1MC-1010MC-1010HGC-27HGC-27FarageFarageSU-DHL-5SU-DHL-5NCI-H929NCI-H929WSU-NHLWSU-NHLHHHHMFE-280MFE-280KASUMI-2KASUMI-2P30-OHKP30-OHKRPMI-8866RPMI-8866JVM-2JVM-2HAL-01HAL-01OCI-LY-7OCI-LY-7KARPAS-231KARPAS-231YTYTSU-DHL-6SU-DHL-6ZR-75-1ZR-75-1UO31UO31HCC1428MDA-MB-157CTB-1LC4-1JL-1SNU-869ROS-50OVSAHOTUHR14TKBNCI-H1688NCI-H524HCC-1195SNU-398COR-L321DJM-1BT498COR-L88LIM1215VMRC-LCDHS578BSTTUHR4TKBNCI-H322MLAMA-84JEG-3L-428RF-48EFE-184SK-MEL-31SNU-489MC-IXC MOLM-16SNU-216DOKYAMATOES5MHH-PREB-1RCH-ACVH3118KARPAS-1106PMOLT-4MEC-1MC-1010HGC-27FarageSU-DHL-5NCI-H929WSU-NHLHHMFE-280KASUMI-2P30-OHKRPMI-8866JVM-2HAL-01OCI-LY-7KARPAS-231YTSU-DHL-6ZR-75-1UO31HCC1428: 10.85 (log10 µM)Synonyms: HCC1428, hcc1428MDA-MB-157: 7.37 (log10 µM)Synonyms: MDA-MB-157, MDAMB157, mdamb157CTB-1: 4.69 (log10 µM)Synonyms: CTB-1LC4-1: 4.26 (log10 µM)Synonyms: LC4-1JL-1: 3.78 (log10 µM)Synonyms: JL-1, JL1SNU-869: 3.66 (log10 µM)Synonyms: SNU-869, SNU869ROS-50: 3.38 (log10 µM)Synonyms: ROS-50OVSAHO: 3.38 (log10 µM)Synonyms: OVSAHOTUHR14TKB: 3.26 (log10 µM)Synonyms: TUHR14TKBNCI-H1688: 3.25 (log10 µM)Synonyms: NCI-H1688NCI-H524: 3.18 (log10 µM)Synonyms: NCI-H524, NCIH524HCC-1195: 3.08 (log10 µM)Synonyms: HCC-1195, HCC1195SNU-398: 2.96 (log10 µM)Synonyms: SNU-398, SNU398COR-L321: 2.92 (log10 µM)Synonyms: COR-L321DJM-1: 2.85 (log10 µM)Synonyms: DJM-1BT498: 2.74 (log10 µM)Synonyms: BT498COR-L88: 2.70 (log10 µM)Synonyms: COR-L88, CORL88LIM1215: 2.62 (log10 µM)Synonyms: LIM1215VMRC-LCD: 2.50 (log10 µM)Synonyms: VMRC-LCD, VMRCLCDHS578BST: 2.45 (log10 µM)Synonyms: HS578BSTTUHR4TKB: 2.42 (log10 µM)Synonyms: TUHR4TKBNCI-H322M: 2.36 (log10 µM)Synonyms: NCI-H322MLAMA-84: 2.35 (log10 µM)Synonyms: LAMA-84, LAMA84JEG-3: 2.33 (log10 µM)Synonyms: JEG-3L-428: 2.30 (log10 µM)Synonyms: L-428, L428RF-48: 2.29 (log10 µM)Synonyms: RF-48EFE-184: 2.26 (log10 µM)Synonyms: EFE-184, EFE184SK-MEL-31: 2.19 (log10 µM)Synonyms: SK-MEL-31, SKMEL31SNU-489: 2.13 (log10 µM)Synonyms: SNU-489, SNU489MC-IXC: 2.12 (log10 µM)Synonyms: MC-IXC : 0.00 (log10 µM)Synonyms: : 0.00 (log10 µM)Synonyms: : 0.00 (log10 µM)Synonyms: : 0.00 (log10 µM)Synonyms: : 0.00 (log10 µM)Synonyms: MOLM-16: -0.76 (log10 µM)Synonyms: MOLM-16, MOLM16SNU-216: -0.78 (log10 µM)Synonyms: SNU-216, SNU216DOK: -0.81 (log10 µM)Synonyms: DOKYAMATO: -0.82 (log10 µM)Synonyms: YAMATOES5: -0.82 (log10 µM)Synonyms: ES5MHH-PREB-1: -0.84 (log10 µM)Synonyms: MHH-PREB-1RCH-ACV: -0.88 (log10 µM)Synonyms: RCH-ACV, RCHACVH3118: -0.89 (log10 µM)Synonyms: H3118KARPAS-1106P: -0.93 (log10 µM)Synonyms: KARPAS-1106PMOLT-4: -0.94 (log10 µM)Synonyms: MOLT-4MEC-1: -0.99 (log10 µM)Synonyms: MEC-1, MEC1MC-1010: -1.00 (log10 µM)Synonyms: MC-1010HGC-27: -1.02 (log10 µM)Synonyms: HGC-27, HGC27Farage: -1.08 (log10 µM)Synonyms: FarageSU-DHL-5: -1.10 (log10 µM)Synonyms: SU-DHL-5NCI-H929: -1.11 (log10 µM)Synonyms: NCI-H929, NCIH929WSU-NHL: -1.11 (log10 µM)Synonyms: WSU-NHLHH: -1.13 (log10 µM)Synonyms: HHMFE-280: -1.16 (log10 µM)Synonyms: MFE-280KASUMI-2: -1.16 (log10 µM)Synonyms: KASUMI-2, KASUMI2P30-OHK: -1.17 (log10 µM)Synonyms: P30-OHKRPMI-8866: -1.23 (log10 µM)Synonyms: RPMI-8866JVM-2: -1.23 (log10 µM)Synonyms: JVM-2, JVM2HAL-01: -1.25 (log10 µM)Synonyms: HAL-01OCI-LY-7: -1.27 (log10 µM)Synonyms: OCI-LY-7, OCI-LY7KARPAS-231: -1.31 (log10 µM)Synonyms: KARPAS-231YT: -1.42 (log10 µM)Synonyms: YTSU-DHL-6: -1.52 (log10 µM)Synonyms: SU-DHL-6, SUDHL6ZR-75-1: -1.83 (log10 µM)Synonyms: ZR-75-1, ZR751, zr751UO31: -1.83 (log10 µM)Synonyms: UO31, UO-31, U031AACpIC50* Plot represents the top and bottom 30 data points** Error Bars represent the Median Absolute Deviation
Download Data as CSV
GDC-0941: AACAACTissues0.000.100.200.300.400.500.600.70neuroblastomaneuroblastomaplacentaplacentapleurapleuralarge_intestinelarge_intestinecervixcervixskinskinadrenal_glandadrenal_glandlunglungcentral_nervous_systemcentral_nervous_systemautonomic_gangliaautonomic_gangliapancreaspancreasendometriumendometriumliverliverprostateprostatethyroidthyroidoesophagusoesophaguskidneykidneyurinary_tracturinary_tractovaryovarybreastbreastsoft_tissuesoft_tissuebiliary_tractbiliary_tractvulvavulvahead_and_neckhead_and_necksmall_intestinesmall_intestinestomachstomachotherotherbonebonehaematopoietic_and_lymphoid_tissuehaematopoietic_and_lymphoid_tissuemiscmisctestistestisupper_aerodigestive_tractupper_aerodigestive_tractunknownunknownoral_cavityoral_cavitysalivary_glandsalivary_gland-2.00-1.50-1.00-0.500.000.501.001.502.002.50oral_cavityoral_cavitysalivary_glandsalivary_glandotherotheradrenal_glandadrenal_glandtestistestisneuroblastomaneuroblastomamiscmisccervixcervixsoft_tissuesoft_tissuehead_and_neckhead_and_neckbreastbreastbonebonehaematopoietic_and_lymphoid_tissuehaematopoietic_and_lymphoid_tissueupper_aerodigestive_tractupper_aerodigestive_tractkidneykidneystomachstomachoesophagusoesophagusautonomic_gangliaautonomic_gangliaovaryovarythyroidthyroidlarge_intestinelarge_intestinelunglungbiliary_tractbiliary_tractvulvavulvaurinary_tracturinary_tractprostateprostateskinskinpancreaspancreascentral_nervous_systemcentral_nervous_systemendometriumendometriumliverliversmall_intestinesmall_intestinepleurapleuraunknownunknownplacentaplacentaAACpIC50= Truncated outliers