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Nutlin-3

Synonyms

SourcesNames Used
CCLENutlin-3
GRAYNutlin 3a
CTRPv2nutlin-3
PharmacoGx Nutlin-3

External IDs

DatabaseIdentifier
Smiles: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Inchikey: BDUHCSBCVGXTJM-UHFFFAOYSA-N
Pubchem: 216345

Annotated Targets

MDM2, TP53

FDA Approval Status

Not Approved
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Top molecular features associated with response to Nutlin-3


Feature TypeStandardized
Nominal ANOVA
mRNA MICAL1 CTRPv2 pan-cancer AAC 0.18 4e-07
mRNA UBR4 CTRPv2 pan-cancer AAC -0.18 4e-07
mRNA PSMB2 CTRPv2 pan-cancer AAC -0.18 4e-07
mRNA RP4-614O4.11 CTRPv2 pan-cancer AAC -0.18 4e-07
mRNA STAU1 CTRPv2 pan-cancer AAC -0.19 4e-07
mRNA OSER1 CTRPv2 pan-cancer AAC -0.18 5e-07
mRNA ZW10 CTRPv2 pan-cancer AAC -0.17 5e-07
mRNA ROMO1 CTRPv2 pan-cancer AAC -0.17 5e-07
mRNA ARHGAP45 CTRPv2 pan-cancer AAC 0.25 5e-07
mRNA ARHGDIG CTRPv2 pan-cancer AAC 0.18 6e-07
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