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PLX4720

PLX4720

Synonyms

Sources	Names Used
CCLE, GDSC1000	PLX4720
CTRPv2	PLX-4720
PharmacoGx	PLX4720

External IDs

Database	Identifier
Smiles:	CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F
Inchikey:	YZDJQTHVDDOVHR-UHFFFAOYSA-N
Pubchem:	24180719

Annotated Targets

BRAF, KDR

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to PLX4720

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	MELTF	CTRPv2	pan-cancer	AAC	0.21	2e-08
mRNA	SEPN1	CTRPv2	pan-cancer	AAC	0.23	3e-08
mRNA	GDNF	CTRPv2	pan-cancer	AAC	0.21	3e-08
mRNA	MPZ	CTRPv2	pan-cancer	AAC	0.2	3e-08
mRNA	LRGUK	CCLE	pan-cancer	AAC	0.27	3e-08
mRNA	CYP27A1	GDSC1000	pan-cancer	AAC	0.2	3e-08
mRNA	ARHGEF40	CTRPv2	pan-cancer	AAC	0.21	3e-08
mRNA	OR2A42	CTRPv2	pan-cancer	AAC	0.2	3e-08
mRNA	CHST11	CTRPv2	pan-cancer	AAC	0.21	4e-08
mRNA	LPL	CCLE	pan-cancer	AAC	0.24	4e-08

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