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PLX4720

Synonyms

SourcesNames Used
CCLE, GDSC1000PLX4720
CTRPv2PLX-4720
PharmacoGx PLX4720

External IDs

DatabaseIdentifier
Smiles: CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F
Inchikey: YZDJQTHVDDOVHR-UHFFFAOYSA-N
Pubchem: 24180719

Annotated Targets

BRAF, KDR

FDA Approval Status

Not Approved
Number of cell lines tested with PLX4720(per dataset)0100200300400500600700800900# cell lines gCSIGRAYFIMMUHNBreastCCLECTRPv2GDSC10000000496830999
Number of tissues tested with PLX4720(per dataset)05101520253035# tissues gCSIGRAYFIMMUHNBreastCCLECTRPv2GDSC10000000222535
Dataset Select
PLX4720: AACAAC0.000.050.100.150.200.250.300.350.400.450.50SIG-M5SIG-M5WM-88WM-88451Lu451LuCP50-MEL-BCP50-MEL-BMMAC-SFMMAC-SFDU-4475DU-4475Malme-3MMalme-3MSH-4SH-4MEL-HOMEL-HOWM-983BWM-983BATN-1ATN-1K5K5IGR-37IGR-37COLO-679COLO-679G-MELG-MELSK-MEL-1SK-MEL-1UACC-62UACC-62ACNACNHT-144HT-144COLO 201COLO 201MZ2-MELMZ2-MELCOLO-205COLO-205WM1799WM1799TI-73TI-73A375A375UACC-257UACC-257RVH-421RVH-421NTERA-2_cl.D1NTERA-2_cl.D1RPMI-8866RPMI-8866M14M14 NCI-H1581NCI-H1581NUGC-4NUGC-4SIMASIMAK1K1NCI-H1105NCI-H1105VCaPVCaPPA-TU-8988TPA-TU-8988TLK-2LK-2GP5dGP5dH2810H2810TMK-1TMK-1SW756SW756CAPAN-1CAPAN-1JHU-019JHU-019MN-60MN-60C-4 IC-4 IHMV-IIHMV-IIOVKATEOVKATE23132-8723132-87OVCA433OVCA433H-EMC-SSH-EMC-SSSCC90SCC90H2804H2804LIM1215LIM1215NB69NB69SN12CSN12CGSUGSUSNU-503SNU-503BT286BT286BT12BT12SIG-M5WM-88451LuCP50-MEL-BMMAC-SFDU-4475Malme-3MSH-4MEL-HOWM-983BATN-1K5IGR-37COLO-679G-MELSK-MEL-1UACC-62ACNHT-144COLO 201MZ2-MELCOLO-205WM1799TI-73A375UACC-257RVH-421NTERA-2_cl.D1RPMI-8866M14 NCI-H1581NUGC-4SIMAK1NCI-H1105VCaPPA-TU-8988TLK-2GP5dH2810TMK-1SW756CAPAN-1JHU-019MN-60C-4 IHMV-IIOVKATE23132-87OVCA433H-EMC-SSSCC90H2804LIM1215NB69SN12CGSUSNU-503BT286BT12SIG-M5: 0.52Synonyms: SIG-M5, SIGM5WM-88: 0.44Synonyms: WM-88, WM88451Lu: 0.43Synonyms: 451LuCP50-MEL-B: 0.40Synonyms: CP50-MEL-BMMAC-SF: 0.40Synonyms: MMAC-SFDU-4475: 0.39Synonyms: DU-4475, DU4475, du4475Malme-3M: 0.38Synonyms: Malme-3M, MALME3MSH-4: 0.38Synonyms: SH-4, SH4MEL-HO: 0.33Synonyms: MEL-HO, MELHOWM-983B: 0.32Synonyms: WM-983B, WM983BATN-1: 0.31Synonyms: ATN-1K5: 0.31Synonyms: K5IGR-37: 0.30Synonyms: IGR-37, IGR37COLO-679: 0.30Synonyms: COLO-679, COLO 679G-MEL: 0.30Synonyms: G-MELSK-MEL-1: 0.29Synonyms: SK-MEL-1, SKMEL1UACC-62: 0.28Synonyms: UACC-62, UACC62ACN: 0.28Synonyms: ACNHT-144: 0.27Synonyms: HT-144, HT144COLO 201: 0.27Synonyms: COLO 201, COLO_201, COLO201MZ2-MEL: 0.27Synonyms: MZ2-MELCOLO-205: 0.27Synonyms: COLO-205, COLO 205, COLO205WM1799: 0.26Synonyms: WM1799TI-73: 0.26Synonyms: TI-73, T1-73A375: 0.25Synonyms: A375, A-375UACC-257: 0.25Synonyms: UACC-257, UACC257RVH-421: 0.25Synonyms: RVH-421, RVH421NTERA-2_cl.D1: 0.25Synonyms: NTERA-2_cl.D1, NTERA-2 cl.D1RPMI-8866: 0.24Synonyms: RPMI-8866M14: 0.24Synonyms: M14 : 0.00Synonyms: : 0.00Synonyms: : 0.00Synonyms: : 0.00Synonyms: : 0.00Synonyms: NCI-H1581: 0.00Synonyms: NCI-H1581, NCIH1581NUGC-4: 0.00Synonyms: NUGC-4, NUGC4SIMA: 0.00Synonyms: SIMAK1: 0.00Synonyms: K1NCI-H1105: 0.00Synonyms: NCI-H1105, NCIH1105VCaP: 0.00Synonyms: VCaP, VCAPPA-TU-8988T: 0.00Synonyms: PA-TU-8988T, PATU8988TLK-2: 0.00Synonyms: LK-2, LK2GP5d: 0.00Synonyms: GP5dH2810: 0.00Synonyms: H2810TMK-1: 0.00Synonyms: TMK-1SW756: 0.00Synonyms: SW756CAPAN-1: 0.00Synonyms: CAPAN-1, Capan-1, CAPAN1JHU-019: 0.00Synonyms: JHU-019MN-60: 0.00Synonyms: MN-60C-4 I: 0.00Synonyms: C-4 I, C-4-IHMV-II: 0.00Synonyms: HMV-II, HMVIIOVKATE: 0.00Synonyms: OVKATE23132-87: 0.00Synonyms: 23132-87, 23132/87, 23132_87, 2313287OVCA433: 0.00Synonyms: OVCA433H-EMC-SS: 0.00Synonyms: H-EMC-SSSCC90: 0.00Synonyms: SCC90H2804: 0.00Synonyms: H2804LIM1215: 0.00Synonyms: LIM1215NB69: 0.00Synonyms: NB69SN12C: 0.00Synonyms: SN12CGSU: 0.00Synonyms: GSUSNU-503: 0.00Synonyms: SNU-503, SNU503BT286: 0.00Synonyms: BT286BT12: 0.00Synonyms: BT120.002.004.006.008.0010.0012.0014.0016.0018.0020.0022.00OS-RC-2OS-RC-2HCC202HCC202HAL-01HAL-01M059JM059JRS4;11RS4;11EW-16EW-16639-V639-VSBC-3SBC-3SJRH30SJRH30SNU-387SNU-387JHH-7JHH-7JHOS-4JHOS-4KYSE-30KYSE-30ARH-77ARH-77NCI-H2227NCI-H2227MewoMewoDMS-114DMS-114EW-3EW-3HCC1419HCC1419YAPCYAPCFTC-133FTC-133COR-L88COR-L88VM-CUB-1VM-CUB-1IMR-5IMR-5LN-405LN-405SU-DHL-16SU-DHL-16UDSCC2UDSCC2JURKATJURKATMS751MS751RPMI-7951RPMI-7951 HTC-C3HTC-C3C32C32WM1799WM1799K5K5COLO-205COLO-205COLO 201COLO 201UACC-257UACC-257NTERA-2_cl.D1NTERA-2_cl.D1SK-MEL-1SK-MEL-1LS-411NLS-411NACNACNBHT-101BHT-101WM-115WM-115UACC-62UACC-62SK-MEL-28SK-MEL-28WM-983BWM-983BDU-4475DU-4475COLO-679COLO-679WM35WM35CP50-MEL-BCP50-MEL-BM14M14MEL-HOMEL-HOMMAC-SFMMAC-SFMalme-3MMalme-3MG-MELG-MELSH-4SH-4A375A375451Lu451LuWM-88WM-88IGR-37IGR-37OS-RC-2HCC202HAL-01M059JRS4;11EW-16639-VSBC-3SJRH30SNU-387JHH-7JHOS-4KYSE-30ARH-77NCI-H2227MewoDMS-114EW-3HCC1419YAPCFTC-133COR-L88VM-CUB-1IMR-5LN-405SU-DHL-16UDSCC2JURKATMS751RPMI-7951 HTC-C3C32WM1799K5COLO-205COLO 201UACC-257NTERA-2_cl.D1SK-MEL-1LS-411NACNBHT-101WM-115UACC-62SK-MEL-28WM-983BDU-4475COLO-679WM35CP50-MEL-BM14MEL-HOMMAC-SFMalme-3MG-MELSH-4A375451LuWM-88IGR-37OS-RC-2: 23.69 (log10 µM)Synonyms: OS-RC-2, OSRC2HCC202: 12.50 (log10 µM)Synonyms: HCC202, hcc202HAL-01: 11.12 (log10 µM)Synonyms: HAL-01M059J: 10.94 (log10 µM)Synonyms: M059JRS4;11: 10.05 (log10 µM)Synonyms: RS4;11, RS4_11, RS4-11, RS411EW-16: 9.64 (log10 µM)Synonyms: EW-16639-V: 9.59 (log10 µM)Synonyms: 639-V, 639VSBC-3: 9.07 (log10 µM)Synonyms: SBC-3SJRH30: 8.99 (log10 µM)Synonyms: SJRH30SNU-387: 8.90 (log10 µM)Synonyms: SNU-387, SNU387JHH-7: 8.41 (log10 µM)Synonyms: JHH-7JHOS-4: 8.36 (log10 µM)Synonyms: JHOS-4KYSE-30: 7.98 (log10 µM)Synonyms: KYSE-30, KYSE30ARH-77: 7.70 (log10 µM)Synonyms: ARH-77NCI-H2227: 7.26 (log10 µM)Synonyms: NCI-H2227Mewo: 7.23 (log10 µM)Synonyms: Mewo, MeWo, MEWODMS-114: 7.07 (log10 µM)Synonyms: DMS-114, DMS 114, DMS_114, DMS114EW-3: 6.74 (log10 µM)Synonyms: EW-3HCC1419: 6.65 (log10 µM)Synonyms: HCC1419, hcc1419YAPC: 6.19 (log10 µM)Synonyms: YAPCFTC-133: 6.11 (log10 µM)Synonyms: FTC-133, FTC133COR-L88: 6.01 (log10 µM)Synonyms: COR-L88, CORL88VM-CUB-1: 6.00 (log10 µM)Synonyms: VM-CUB-1, VM-CUB1, VMCUB1IMR-5: 5.81 (log10 µM)Synonyms: IMR-5LN-405: 5.70 (log10 µM)Synonyms: LN-405SU-DHL-16: 5.62 (log10 µM)Synonyms: SU-DHL-16UDSCC2: 5.58 (log10 µM)Synonyms: UDSCC2JURKAT: 5.56 (log10 µM)Synonyms: JURKAT, JurkatMS751: 5.55 (log10 µM)Synonyms: MS751RPMI-7951: 5.51 (log10 µM)Synonyms: RPMI-7951, RPMI7951 : 0.00 (log10 µM)Synonyms: : 0.00 (log10 µM)Synonyms: : 0.00 (log10 µM)Synonyms: : 0.00 (log10 µM)Synonyms: : 0.00 (log10 µM)Synonyms: HTC-C3: 0.21 (log10 µM)Synonyms: HTC-C3C32: 0.19 (log10 µM)Synonyms: C32WM1799: 0.19 (log10 µM)Synonyms: WM1799K5: 0.14 (log10 µM)Synonyms: K5COLO-205: 0.10 (log10 µM)Synonyms: COLO-205, COLO 205, COLO205COLO 201: 0.09 (log10 µM)Synonyms: COLO 201, COLO_201, COLO201UACC-257: 0.09 (log10 µM)Synonyms: UACC-257, UACC257NTERA-2_cl.D1: 0.08 (log10 µM)Synonyms: NTERA-2_cl.D1, NTERA-2 cl.D1SK-MEL-1: 0.06 (log10 µM)Synonyms: SK-MEL-1, SKMEL1LS-411N: 0.02 (log10 µM)Synonyms: LS-411N, LS411NACN: 0.00 (log10 µM)Synonyms: ACNBHT-101: -0.03 (log10 µM)Synonyms: BHT-101, BHT101WM-115: -0.05 (log10 µM)Synonyms: WM-115, WM115UACC-62: -0.08 (log10 µM)Synonyms: UACC-62, UACC62SK-MEL-28: -0.14 (log10 µM)Synonyms: SK-MEL-28, SKMEL28WM-983B: -0.17 (log10 µM)Synonyms: WM-983B, WM983BDU-4475: -0.23 (log10 µM)Synonyms: DU-4475, DU4475, du4475COLO-679: -0.24 (log10 µM)Synonyms: COLO-679, COLO 679WM35: -0.27 (log10 µM)Synonyms: WM35CP50-MEL-B: -0.29 (log10 µM)Synonyms: CP50-MEL-BM14: -0.32 (log10 µM)Synonyms: M14MEL-HO: -0.34 (log10 µM)Synonyms: MEL-HO, MELHOMMAC-SF: -0.38 (log10 µM)Synonyms: MMAC-SFMalme-3M: -0.44 (log10 µM)Synonyms: Malme-3M, MALME3MG-MEL: -0.47 (log10 µM)Synonyms: G-MELSH-4: -0.48 (log10 µM)Synonyms: SH-4, SH4A375: -0.49 (log10 µM)Synonyms: A375, A-375451Lu: -0.50 (log10 µM)Synonyms: 451LuWM-88: -0.65 (log10 µM)Synonyms: WM-88, WM88IGR-37: -0.77 (log10 µM)Synonyms: IGR-37, IGR37AACpIC50* Plot represents the top and bottom 30 data points** Error Bars represent the Median Absolute Deviation
Download Data as CSV
PLX4720: AACAACTissues0.000.050.100.150.200.250.300.350.400.450.50adrenal_glandadrenal_glandplacentaplacentacervixcervixpleurapleuraoral_cavityoral_cavityautonomic_gangliaautonomic_gangliaunknownunknownprostateprostatelarge_intestinelarge_intestinebreastbreastendometriumendometriumlunglungurinary_tracturinary_tractstomachstomachpancreaspancreascentral_nervous_systemcentral_nervous_systemvulvavulvakidneykidneyliverliverovaryovaryoesophagusoesophagussoft_tissuesoft_tissuebonebonebiliary_tractbiliary_tractupper_aerodigestive_tractupper_aerodigestive_tractmiscmiscotherotherhaematopoietic_and_lymphoid_tissuehaematopoietic_and_lymphoid_tissuehead_and_neckhead_and_neckthyroidthyroidtestistestissalivary_glandsalivary_glandsmall_intestinesmall_intestineneuroblastomaneuroblastomaskinskin-0.500.000.501.001.502.002.503.003.50breastbreastsalivary_glandsalivary_glandplacentaplacentasmall_intestinesmall_intestineneuroblastomaneuroblastomatestistestislarge_intestinelarge_intestineprostateprostateskinskinotherotherthyroidthyroidhead_and_neckhead_and_neckcervixcervixoesophagusoesophaguspancreaspancreasautonomic_gangliaautonomic_gangliapleurapleuralunglungadrenal_glandadrenal_glandcentral_nervous_systemcentral_nervous_systemsoft_tissuesoft_tissuebiliary_tractbiliary_tractendometriumendometriumvulvavulvaboneboneovaryovaryurinary_tracturinary_tractkidneykidneyhaematopoietic_and_lymphoid_tissuehaematopoietic_and_lymphoid_tissuestomachstomachupper_aerodigestive_tractupper_aerodigestive_tractliverlivermiscmiscoral_cavityoral_cavityunknownunknownAACpIC50= Truncated outliers