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PLX4720
PLX4720
Synonyms
Sources
Names Used
CCLE
,
GDSC1000
PLX4720
CTRPv2
PLX-4720
PharmacoGx
PLX4720
External IDs
Database
Identifier
Smiles:
CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F
Inchikey:
YZDJQTHVDDOVHR-UHFFFAOYSA-N
Pubchem:
24180719
Annotated Targets
BRAF
,
KDR
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with PLX4720
(per dataset)
0
100
200
300
400
500
600
700
800
900
# cell lines
gCSI
GRAY
FIMM
UHNBreast
CCLE
CTRPv2
GDSC1000
0
0
0
0
496
830
999
Download SVG
Number of tissues tested with PLX4720
(per dataset)
0
5
10
15
20
25
30
35
# tissues
gCSI
GRAY
FIMM
UHNBreast
CCLE
CTRPv2
GDSC1000
0
0
0
0
22
25
35
Download SVG
Dataset Select
all
CCLE
GDSC1000
CTRPv2
PLX4720: AAC
AAC
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
SIG-M5
SIG-M5
WM-88
WM-88
451Lu
451Lu
CP50-MEL-B
CP50-MEL-B
MMAC-SF
MMAC-SF
DU-4475
DU-4475
Malme-3M
Malme-3M
SH-4
SH-4
MEL-HO
MEL-HO
WM-983B
WM-983B
ATN-1
ATN-1
K5
K5
IGR-37
IGR-37
COLO-679
COLO-679
G-MEL
G-MEL
SK-MEL-1
SK-MEL-1
UACC-62
UACC-62
ACN
ACN
HT-144
HT-144
COLO 201
COLO 201
MZ2-MEL
MZ2-MEL
COLO-205
COLO-205
WM1799
WM1799
TI-73
TI-73
A375
A375
UACC-257
UACC-257
RVH-421
RVH-421
NTERA-2_cl.D1
NTERA-2_cl.D1
RPMI-8866
RPMI-8866
M14
M14
NCI-H1581
NCI-H1581
NUGC-4
NUGC-4
SIMA
SIMA
K1
K1
NCI-H1105
NCI-H1105
VCaP
VCaP
PA-TU-8988T
PA-TU-8988T
LK-2
LK-2
GP5d
GP5d
H2810
H2810
TMK-1
TMK-1
SW756
SW756
CAPAN-1
CAPAN-1
JHU-019
JHU-019
MN-60
MN-60
C-4 I
C-4 I
HMV-II
HMV-II
OVKATE
OVKATE
23132-87
23132-87
OVCA433
OVCA433
H-EMC-SS
H-EMC-SS
SCC90
SCC90
H2804
H2804
LIM1215
LIM1215
NB69
NB69
SN12C
SN12C
GSU
GSU
SNU-503
SNU-503
BT286
BT286
BT12
BT12
SIG-M5
WM-88
451Lu
CP50-MEL-B
MMAC-SF
DU-4475
Malme-3M
SH-4
MEL-HO
WM-983B
ATN-1
K5
IGR-37
COLO-679
G-MEL
SK-MEL-1
UACC-62
ACN
HT-144
COLO 201
MZ2-MEL
COLO-205
WM1799
TI-73
A375
UACC-257
RVH-421
NTERA-2_cl.D1
RPMI-8866
M14
NCI-H1581
NUGC-4
SIMA
K1
NCI-H1105
VCaP
PA-TU-8988T
LK-2
GP5d
H2810
TMK-1
SW756
CAPAN-1
JHU-019
MN-60
C-4 I
HMV-II
OVKATE
23132-87
OVCA433
H-EMC-SS
SCC90
H2804
LIM1215
NB69
SN12C
GSU
SNU-503
BT286
BT12
SIG-M5: 0.52
Synonyms: SIG-M5, SIGM5
WM-88: 0.44
Synonyms: WM-88, WM88
451Lu: 0.43
Synonyms: 451Lu
CP50-MEL-B: 0.40
Synonyms: CP50-MEL-B
MMAC-SF: 0.40
Synonyms: MMAC-SF
DU-4475: 0.39
Synonyms: DU-4475, DU4475, du4475
Malme-3M: 0.38
Synonyms: Malme-3M, MALME3M
SH-4: 0.38
Synonyms: SH-4, SH4
MEL-HO: 0.33
Synonyms: MEL-HO, MELHO
WM-983B: 0.32
Synonyms: WM-983B, WM983B
ATN-1: 0.31
Synonyms: ATN-1
K5: 0.31
Synonyms: K5
IGR-37: 0.30
Synonyms: IGR-37, IGR37
COLO-679: 0.30
Synonyms: COLO-679, COLO 679
G-MEL: 0.30
Synonyms: G-MEL
SK-MEL-1: 0.29
Synonyms: SK-MEL-1, SKMEL1
UACC-62: 0.28
Synonyms: UACC-62, UACC62
ACN: 0.28
Synonyms: ACN
HT-144: 0.27
Synonyms: HT-144, HT144
COLO 201: 0.27
Synonyms: COLO 201, COLO_201, COLO201
MZ2-MEL: 0.27
Synonyms: MZ2-MEL
COLO-205: 0.27
Synonyms: COLO-205, COLO 205, COLO205
WM1799: 0.26
Synonyms: WM1799
TI-73: 0.26
Synonyms: TI-73, T1-73
A375: 0.25
Synonyms: A375, A-375
UACC-257: 0.25
Synonyms: UACC-257, UACC257
RVH-421: 0.25
Synonyms: RVH-421, RVH421
NTERA-2_cl.D1: 0.25
Synonyms: NTERA-2_cl.D1, NTERA-2 cl.D1
RPMI-8866: 0.24
Synonyms: RPMI-8866
M14: 0.24
Synonyms: M14
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
NCI-H1581: 0.00
Synonyms: NCI-H1581, NCIH1581
NUGC-4: 0.00
Synonyms: NUGC-4, NUGC4
SIMA: 0.00
Synonyms: SIMA
K1: 0.00
Synonyms: K1
NCI-H1105: 0.00
Synonyms: NCI-H1105, NCIH1105
VCaP: 0.00
Synonyms: VCaP, VCAP
PA-TU-8988T: 0.00
Synonyms: PA-TU-8988T, PATU8988T
LK-2: 0.00
Synonyms: LK-2, LK2
GP5d: 0.00
Synonyms: GP5d
H2810: 0.00
Synonyms: H2810
TMK-1: 0.00
Synonyms: TMK-1
SW756: 0.00
Synonyms: SW756
CAPAN-1: 0.00
Synonyms: CAPAN-1, Capan-1, CAPAN1
JHU-019: 0.00
Synonyms: JHU-019
MN-60: 0.00
Synonyms: MN-60
C-4 I: 0.00
Synonyms: C-4 I, C-4-I
HMV-II: 0.00
Synonyms: HMV-II, HMVII
OVKATE: 0.00
Synonyms: OVKATE
23132-87: 0.00
Synonyms: 23132-87, 23132/87, 23132_87, 2313287
OVCA433: 0.00
Synonyms: OVCA433
H-EMC-SS: 0.00
Synonyms: H-EMC-SS
SCC90: 0.00
Synonyms: SCC90
H2804: 0.00
Synonyms: H2804
LIM1215: 0.00
Synonyms: LIM1215
NB69: 0.00
Synonyms: NB69
SN12C: 0.00
Synonyms: SN12C
GSU: 0.00
Synonyms: GSU
SNU-503: 0.00
Synonyms: SNU-503, SNU503
BT286: 0.00
Synonyms: BT286
BT12: 0.00
Synonyms: BT12
Download SVG
0.00
2.00
4.00
6.00
8.00
10.00
12.00
14.00
16.00
18.00
20.00
22.00
OS-RC-2
OS-RC-2
HCC202
HCC202
HAL-01
HAL-01
M059J
M059J
RS4;11
RS4;11
EW-16
EW-16
639-V
639-V
SBC-3
SBC-3
SJRH30
SJRH30
SNU-387
SNU-387
JHH-7
JHH-7
JHOS-4
JHOS-4
KYSE-30
KYSE-30
ARH-77
ARH-77
NCI-H2227
NCI-H2227
Mewo
Mewo
DMS-114
DMS-114
EW-3
EW-3
HCC1419
HCC1419
YAPC
YAPC
FTC-133
FTC-133
COR-L88
COR-L88
VM-CUB-1
VM-CUB-1
IMR-5
IMR-5
LN-405
LN-405
SU-DHL-16
SU-DHL-16
UDSCC2
UDSCC2
JURKAT
JURKAT
MS751
MS751
RPMI-7951
RPMI-7951
HTC-C3
HTC-C3
C32
C32
WM1799
WM1799
K5
K5
COLO-205
COLO-205
COLO 201
COLO 201
UACC-257
UACC-257
NTERA-2_cl.D1
NTERA-2_cl.D1
SK-MEL-1
SK-MEL-1
LS-411N
LS-411N
ACN
ACN
BHT-101
BHT-101
WM-115
WM-115
UACC-62
UACC-62
SK-MEL-28
SK-MEL-28
WM-983B
WM-983B
DU-4475
DU-4475
COLO-679
COLO-679
WM35
WM35
CP50-MEL-B
CP50-MEL-B
M14
M14
MEL-HO
MEL-HO
MMAC-SF
MMAC-SF
Malme-3M
Malme-3M
G-MEL
G-MEL
SH-4
SH-4
A375
A375
451Lu
451Lu
WM-88
WM-88
IGR-37
IGR-37
OS-RC-2
HCC202
HAL-01
M059J
RS4;11
EW-16
639-V
SBC-3
SJRH30
SNU-387
JHH-7
JHOS-4
KYSE-30
ARH-77
NCI-H2227
Mewo
DMS-114
EW-3
HCC1419
YAPC
FTC-133
COR-L88
VM-CUB-1
IMR-5
LN-405
SU-DHL-16
UDSCC2
JURKAT
MS751
RPMI-7951
HTC-C3
C32
WM1799
K5
COLO-205
COLO 201
UACC-257
NTERA-2_cl.D1
SK-MEL-1
LS-411N
ACN
BHT-101
WM-115
UACC-62
SK-MEL-28
WM-983B
DU-4475
COLO-679
WM35
CP50-MEL-B
M14
MEL-HO
MMAC-SF
Malme-3M
G-MEL
SH-4
A375
451Lu
WM-88
IGR-37
OS-RC-2: 23.69 (log10 µM)
Synonyms: OS-RC-2, OSRC2
HCC202: 12.50 (log10 µM)
Synonyms: HCC202, hcc202
HAL-01: 11.12 (log10 µM)
Synonyms: HAL-01
M059J: 10.94 (log10 µM)
Synonyms: M059J
RS4;11: 10.05 (log10 µM)
Synonyms: RS4;11, RS4_11, RS4-11, RS411
EW-16: 9.64 (log10 µM)
Synonyms: EW-16
639-V: 9.59 (log10 µM)
Synonyms: 639-V, 639V
SBC-3: 9.07 (log10 µM)
Synonyms: SBC-3
SJRH30: 8.99 (log10 µM)
Synonyms: SJRH30
SNU-387: 8.90 (log10 µM)
Synonyms: SNU-387, SNU387
JHH-7: 8.41 (log10 µM)
Synonyms: JHH-7
JHOS-4: 8.36 (log10 µM)
Synonyms: JHOS-4
KYSE-30: 7.98 (log10 µM)
Synonyms: KYSE-30, KYSE30
ARH-77: 7.70 (log10 µM)
Synonyms: ARH-77
NCI-H2227: 7.26 (log10 µM)
Synonyms: NCI-H2227
Mewo: 7.23 (log10 µM)
Synonyms: Mewo, MeWo, MEWO
DMS-114: 7.07 (log10 µM)
Synonyms: DMS-114, DMS 114, DMS_114, DMS114
EW-3: 6.74 (log10 µM)
Synonyms: EW-3
HCC1419: 6.65 (log10 µM)
Synonyms: HCC1419, hcc1419
YAPC: 6.19 (log10 µM)
Synonyms: YAPC
FTC-133: 6.11 (log10 µM)
Synonyms: FTC-133, FTC133
COR-L88: 6.01 (log10 µM)
Synonyms: COR-L88, CORL88
VM-CUB-1: 6.00 (log10 µM)
Synonyms: VM-CUB-1, VM-CUB1, VMCUB1
IMR-5: 5.81 (log10 µM)
Synonyms: IMR-5
LN-405: 5.70 (log10 µM)
Synonyms: LN-405
SU-DHL-16: 5.62 (log10 µM)
Synonyms: SU-DHL-16
UDSCC2: 5.58 (log10 µM)
Synonyms: UDSCC2
JURKAT: 5.56 (log10 µM)
Synonyms: JURKAT, Jurkat
MS751: 5.55 (log10 µM)
Synonyms: MS751
RPMI-7951: 5.51 (log10 µM)
Synonyms: RPMI-7951, RPMI7951
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
HTC-C3: 0.21 (log10 µM)
Synonyms: HTC-C3
C32: 0.19 (log10 µM)
Synonyms: C32
WM1799: 0.19 (log10 µM)
Synonyms: WM1799
K5: 0.14 (log10 µM)
Synonyms: K5
COLO-205: 0.10 (log10 µM)
Synonyms: COLO-205, COLO 205, COLO205
COLO 201: 0.09 (log10 µM)
Synonyms: COLO 201, COLO_201, COLO201
UACC-257: 0.09 (log10 µM)
Synonyms: UACC-257, UACC257
NTERA-2_cl.D1: 0.08 (log10 µM)
Synonyms: NTERA-2_cl.D1, NTERA-2 cl.D1
SK-MEL-1: 0.06 (log10 µM)
Synonyms: SK-MEL-1, SKMEL1
LS-411N: 0.02 (log10 µM)
Synonyms: LS-411N, LS411N
ACN: 0.00 (log10 µM)
Synonyms: ACN
BHT-101: -0.03 (log10 µM)
Synonyms: BHT-101, BHT101
WM-115: -0.05 (log10 µM)
Synonyms: WM-115, WM115
UACC-62: -0.08 (log10 µM)
Synonyms: UACC-62, UACC62
SK-MEL-28: -0.14 (log10 µM)
Synonyms: SK-MEL-28, SKMEL28
WM-983B: -0.17 (log10 µM)
Synonyms: WM-983B, WM983B
DU-4475: -0.23 (log10 µM)
Synonyms: DU-4475, DU4475, du4475
COLO-679: -0.24 (log10 µM)
Synonyms: COLO-679, COLO 679
WM35: -0.27 (log10 µM)
Synonyms: WM35
CP50-MEL-B: -0.29 (log10 µM)
Synonyms: CP50-MEL-B
M14: -0.32 (log10 µM)
Synonyms: M14
MEL-HO: -0.34 (log10 µM)
Synonyms: MEL-HO, MELHO
MMAC-SF: -0.38 (log10 µM)
Synonyms: MMAC-SF
Malme-3M: -0.44 (log10 µM)
Synonyms: Malme-3M, MALME3M
G-MEL: -0.47 (log10 µM)
Synonyms: G-MEL
SH-4: -0.48 (log10 µM)
Synonyms: SH-4, SH4
A375: -0.49 (log10 µM)
Synonyms: A375, A-375
451Lu: -0.50 (log10 µM)
Synonyms: 451Lu
WM-88: -0.65 (log10 µM)
Synonyms: WM-88, WM88
IGR-37: -0.77 (log10 µM)
Synonyms: IGR-37, IGR37
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
PLX4720: AAC
AAC
Tissues
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
adrenal_gland
adrenal_gland
placenta
placenta
cervix
cervix
pleura
pleura
oral_cavity
oral_cavity
autonomic_ganglia
autonomic_ganglia
unknown
unknown
prostate
prostate
large_intestine
large_intestine
breast
breast
endometrium
endometrium
lung
lung
urinary_tract
urinary_tract
stomach
stomach
pancreas
pancreas
central_nervous_system
central_nervous_system
vulva
vulva
kidney
kidney
liver
liver
ovary
ovary
oesophagus
oesophagus
soft_tissue
soft_tissue
bone
bone
biliary_tract
biliary_tract
upper_aerodigestive_tract
upper_aerodigestive_tract
misc
misc
other
other
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
head_and_neck
head_and_neck
thyroid
thyroid
testis
testis
salivary_gland
salivary_gland
small_intestine
small_intestine
neuroblastoma
neuroblastoma
skin
skin
-0.50
0.00
0.50
1.00
1.50
2.00
2.50
3.00
3.50
breast
breast
salivary_gland
salivary_gland
placenta
placenta
small_intestine
small_intestine
neuroblastoma
neuroblastoma
testis
testis
large_intestine
large_intestine
prostate
prostate
skin
skin
other
other
thyroid
thyroid
head_and_neck
head_and_neck
cervix
cervix
oesophagus
oesophagus
pancreas
pancreas
autonomic_ganglia
autonomic_ganglia
pleura
pleura
lung
lung
adrenal_gland
adrenal_gland
central_nervous_system
central_nervous_system
soft_tissue
soft_tissue
biliary_tract
biliary_tract
endometrium
endometrium
vulva
vulva
bone
bone
ovary
ovary
urinary_tract
urinary_tract
kidney
kidney
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
stomach
stomach
upper_aerodigestive_tract
upper_aerodigestive_tract
liver
liver
misc
misc
oral_cavity
oral_cavity
unknown
unknown
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to PLX4720
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
RXRG
CTRPv2
pan-cancer
AAC
0.38
6e-22
mRNA
SPRY4
CTRPv2
pan-cancer
AAC
0.35
2e-21
mRNA
MMP8
GDSC1000
pan-cancer
AAC
0.35
3e-20
mRNA
MIA-RAB4B
CTRPv2
pan-cancer
AAC
0.37
8e-20
mRNA
CTHRC1
CTRPv2
pan-cancer
AAC
0.33
1e-19
mRNA
NFATC2
CTRPv2
pan-cancer
AAC
0.37
3e-19
mRNA
INPP5F
CTRPv2
pan-cancer
AAC
0.41
5e-19
mRNA
MYL10
CTRPv2
pan-cancer
AAC
0.3
2e-18
mRNA
ITGB3
CTRPv2
pan-cancer
AAC
0.35
4e-18
mRNA
MIA
CTRPv2
pan-cancer
AAC
0.35
4e-18
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