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PLX4720

PLX4720

Synonyms

Sources	Names Used
CCLE, GDSC1000	PLX4720
CTRPv2	PLX-4720
PharmacoGx	PLX4720

External IDs

Database	Identifier
Smiles:	CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F
Inchikey:	YZDJQTHVDDOVHR-UHFFFAOYSA-N
Pubchem:	24180719

Annotated Targets

BRAF, KDR

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to PLX4720

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	HHAT	CTRPv2	pan-cancer	AAC	0.18	1e-06
mRNA	FAM89A	CTRPv2	pan-cancer	AAC	0.18	1e-06
mRNA	ETV4	CCLE	pan-cancer	AAC	0.23	1e-06
mRNA	HMG20B	CTRPv2	pan-cancer	AAC	0.21	1e-06
mRNA	GHR	CCLE	pan-cancer	AAC	0.23	1e-06
mRNA	NACC2	CCLE	pan-cancer	AAC	0.25	2e-06
mRNA	TMEM67	CTRPv2	pan-cancer	AAC	0.17	2e-06
mRNA	CALML3	CTRPv2	pan-cancer	AAC	0.17	2e-06
mRNA	BTBD19	CTRPv2	pan-cancer	AAC	0.18	2e-06
mRNA	PMP2	CCLE	pan-cancer	AAC	0.25	2e-06

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