PharmacoDB

Sources

Names Used

17-AAG

Tanespimycin

tanespimycin

PharmacoGx

17-AAG

Database	Identifier
Smiles:	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC
Inchikey:	AYUNIORJHRXIBJ-TXHRRWQRSA-N
Pubchem:	6505803

Database

Identifier

Smiles:

CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC

Inchikey:

AYUNIORJHRXIBJ-TXHRRWQRSA-N

Pubchem:

Top molecular features associated with response to 17-AAG

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	S100A16	GDSC1000	pan-cancer	AAC	0.25	9e-09
mRNA	GBE1	GDSC1000	pan-cancer	AAC	0.2	9e-09
mRNA	SALL2	GDSC1000	pan-cancer	AAC	-0.21	9e-09
mRNA	UBA52	GDSC1000	pan-cancer	AAC	-0.2	9e-09
mRNA	CD44	GDSC1000	pan-cancer	AAC	0.2	9e-09
mRNA	HSF2	GDSC1000	pan-cancer	AAC	-0.2	9e-09
mRNA	SMARCA4	GDSC1000	pan-cancer	AAC	-0.19	1e-08
mRNA	AIFM2	CCLE	pan-cancer	AAC	0.28	1e-08
mRNA	ISL1	GDSC1000	pan-cancer	AAC	-0.22	1e-08
mRNA	FNDC3B	GDSC1000	pan-cancer	AAC	0.2	1e-08