PharmacoDB

Sources

Names Used

17-AAG

Tanespimycin

tanespimycin

PharmacoGx

17-AAG

Database	Identifier
Smiles:	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC
Inchikey:	AYUNIORJHRXIBJ-TXHRRWQRSA-N
Pubchem:	6505803

Database

Identifier

Smiles:

CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC

Inchikey:

AYUNIORJHRXIBJ-TXHRRWQRSA-N

Pubchem:

Top molecular features associated with response to 17-AAG

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	EPB41	GDSC1000	pan-cancer	AAC	-0.24	2e-11
mRNA	ERRFI1	GDSC1000	pan-cancer	AAC	0.33	2e-11
mRNA	CHD7	GDSC1000	pan-cancer	AAC	-0.24	2e-11
mRNA	MARK1	GDSC1000	pan-cancer	AAC	-0.24	2e-11
mRNA	RAB11FIP5	GDSC1000	pan-cancer	AAC	0.27	2e-11
mRNA	CHGB	GDSC1000	pan-cancer	AAC	-0.24	3e-11
mRNA	STX4	GDSC1000	pan-cancer	AAC	0.22	3e-11
mRNA	DOCK5	GDSC1000	pan-cancer	AAC	0.22	3e-11
mRNA	TXN	GDSC1000	pan-cancer	AAC	0.22	3e-11
mRNA	PROCR	GDSC1000	pan-cancer	AAC	0.25	3e-11