PharmacoDB

Sources

Names Used

17-AAG

Tanespimycin

tanespimycin

PharmacoGx

17-AAG

Database	Identifier
Smiles:	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC
Inchikey:	AYUNIORJHRXIBJ-TXHRRWQRSA-N
Pubchem:	6505803

Database

Identifier

Smiles:

CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC

Inchikey:

AYUNIORJHRXIBJ-TXHRRWQRSA-N

Pubchem:

Top molecular features associated with response to 17-AAG

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	NRSN1	GDSC1000	pan-cancer	AAC	-0.25	8e-12
mRNA	RHOC	GDSC1000	pan-cancer	AAC	0.26	8e-12
mRNA	SUCLG2	GDSC1000	pan-cancer	AAC	0.23	9e-12
mRNA	FUCA2	GDSC1000	pan-cancer	AAC	0.25	9e-12
mRNA	BSN	GDSC1000	pan-cancer	AAC	-0.24	9e-12
mRNA	E2F2	GDSC1000	pan-cancer	AAC	-0.26	1e-11
mRNA	PCSK2	GDSC1000	pan-cancer	AAC	-0.23	1e-11
mRNA	S100A6	GDSC1000	pan-cancer	AAC	0.26	1e-11
mRNA	MPG	GDSC1000	pan-cancer	AAC	0.22	1e-11
mRNA	KCNN4	GDSC1000	pan-cancer	AAC	0.22	1e-11