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AZD-2281

AZD-2281

Synonyms

Sources	Names Used
GDSC1000, FIMM	Olaparib
CTRPv2	olaparib
PharmacoGx	AZD-2281

External IDs

Database	Identifier
Smiles:	C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
Inchikey:	FDLYAMZZIXQODN-UHFFFAOYSA-N
Pubchem:	23725625

FDA Approval Status

Approved

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Top molecular features associated with response to AZD-2281

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ARHGAP19-SLIT1	CTRPv2	pan-cancer	AAC	0.24	3e-09
mRNA	SFPQ	CTRPv2	pan-cancer	AAC	0.22	3e-09
mRNA	ZNF724	CTRPv2	pan-cancer	AAC	0.21	3e-09
mRNA	ZKSCAN2	CTRPv2	pan-cancer	AAC	0.22	3e-09
mRNA	DYRK3	CTRPv2	pan-cancer	AAC	0.21	4e-09
mRNA	PARP1	CTRPv2	pan-cancer	AAC	0.23	4e-09
mRNA	POLH	CTRPv2	pan-cancer	AAC	0.22	4e-09
mRNA	ZNF397	CTRPv2	pan-cancer	AAC	0.21	4e-09
mRNA	RCBTB1	CTRPv2	pan-cancer	AAC	0.21	4e-09
mRNA	ABHD17B	CTRPv2	pan-cancer	AAC	0.22	4e-09

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