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dabrafenib

Synonyms

SourcesNames Used
GDSC1000Dabrafenib
CTRPv2dabrafenib
PharmacoGx dabrafenib

External IDs

DatabaseIdentifier
Smiles: CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F
Pubchem: 44462760

Annotated Targets

BRAF, LIMK1, NEK11, RAF1, SIK1

FDA Approval Status

Approved
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Top molecular features associated with response to dabrafenib


Feature TypeStandardized
Nominal ANOVA
mRNA WDR63 CTRPv2 pan-cancer AAC 0.3 2e-09
mRNA OR2A42 CTRPv2 pan-cancer AAC 0.29 2e-09
mRNA MCFD2 GDSC1000 pan-cancer AAC 0.19 2e-09
mRNA RETSAT GDSC1000 pan-cancer AAC 0.2 2e-09
mRNA HMG20B CTRPv2 pan-cancer AAC 0.35 2e-09
mRNA KIR3DL1 GDSC1000 pan-cancer AAC 0.17 2e-09
mRNA IFT81 CTRPv2 pan-cancer AAC 0.3 2e-09
mRNA PDCD1 CTRPv2 pan-cancer AAC 0.27 2e-09
mRNA SDC3 GDSC1000 pan-cancer AAC 0.21 2e-09
mRNA FNTB CTRPv2 pan-cancer AAC 0.33 2e-09
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