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dabrafenib

Synonyms

SourcesNames Used
GDSC1000Dabrafenib
CTRPv2dabrafenib
PharmacoGx dabrafenib

External IDs

DatabaseIdentifier
Smiles: CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F
Pubchem: 44462760

Annotated Targets

BRAF, LIMK1, NEK11, RAF1, SIK1

FDA Approval Status

Approved
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Top molecular features associated with response to dabrafenib


Feature TypeStandardized
Nominal ANOVA
mRNA SPRY4 CTRPv2 pan-cancer AAC 0.47 1e-24
mRNA SLC45A2 GDSC1000 pan-cancer AAC 0.37 1e-21
mRNA MMP8 GDSC1000 pan-cancer AAC 0.34 5e-21
mRNA GAPDHS GDSC1000 pan-cancer AAC 0.28 7e-19
mRNA NFATC2 CTRPv2 pan-cancer AAC 0.46 9e-19
mRNA CPN1 GDSC1000 pan-cancer AAC 0.34 2e-18
mRNA MYL10 CTRPv2 pan-cancer AAC 0.38 9e-18
mRNA BCL2A1 GDSC1000 pan-cancer AAC 0.29 2e-17
mRNA SDC3 CTRPv2 pan-cancer AAC 0.5 2e-17
mRNA PLP1 GDSC1000 pan-cancer AAC 0.4 3e-17
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