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dabrafenib

Synonyms

SourcesNames Used
GDSC1000Dabrafenib
CTRPv2dabrafenib
PharmacoGx dabrafenib

External IDs

DatabaseIdentifier
Smiles: CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F
Pubchem: 44462760

Annotated Targets

BRAF, LIMK1, NEK11, RAF1, SIK1

FDA Approval Status

Approved
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Top molecular features associated with response to dabrafenib


Feature TypeStandardized
Nominal ANOVA
mRNA TGM2 GDSC1000 pan-cancer AAC 0.19 2e-08
mRNA CD200 CTRPv2 pan-cancer AAC 0.29 2e-08
mRNA FKBP1A CTRPv2 pan-cancer AAC 0.28 2e-08
mRNA CALHM1 CTRPv2 pan-cancer AAC 0.25 2e-08
mRNA PROX1 CTRPv2 pan-cancer AAC 0.26 2e-08
mRNA FGF22 CTRPv2 pan-cancer AAC 0.26 2e-08
mRNA BCAP29 GDSC1000 pan-cancer AAC 0.18 2e-08
mRNA ATOX1 CTRPv2 pan-cancer AAC 0.31 2e-08
mRNA C16orf87 GDSC1000 pan-cancer AAC -0.18 3e-08
mRNA INPP5F GDSC1000 pan-cancer AAC 0.2 3e-08
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