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dabrafenib

Synonyms

SourcesNames Used
GDSC1000Dabrafenib
CTRPv2dabrafenib
PharmacoGx dabrafenib

External IDs

DatabaseIdentifier
Smiles: CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F
Pubchem: 44462760

Annotated Targets

BRAF, LIMK1, NEK11, RAF1, SIK1

FDA Approval Status

Approved
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Top molecular features associated with response to dabrafenib


Feature TypeStandardized
Nominal ANOVA
mRNA PLOD3 CTRPv2 pan-cancer AAC 0.35 1e-08
mRNA QDPR CTRPv2 pan-cancer AAC 0.31 1e-08
mRNA LAMB1 GDSC1000 pan-cancer AAC 0.22 1e-08
mRNA GPR55 CTRPv2 pan-cancer AAC 0.26 1e-08
mRNA SOX30 CTRPv2 pan-cancer AAC 0.26 1e-08
mRNA VGF CTRPv2 pan-cancer AAC 0.26 1e-08
mRNA ARNT2 CTRPv2 pan-cancer AAC 0.34 1e-08
mRNA GALE GDSC1000 pan-cancer AAC 0.19 1e-08
mRNA OAF GDSC1000 pan-cancer AAC 0.19 1e-08
mRNA KLF9 CTRPv2 pan-cancer AAC 0.3 1e-08
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