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dabrafenib

Synonyms

SourcesNames Used
GDSC1000Dabrafenib
CTRPv2dabrafenib
PharmacoGx dabrafenib

External IDs

DatabaseIdentifier
Smiles: CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F
Pubchem: 44462760

Annotated Targets

BRAF, LIMK1, NEK11, RAF1, SIK1

FDA Approval Status

Approved
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Top molecular features associated with response to dabrafenib


Feature TypeStandardized
Nominal ANOVA
mRNA TSNAX CTRPv2 pan-cancer AAC 0.29 1e-08
mRNA GRIK2 CTRPv2 pan-cancer AAC 0.3 1e-08
mRNA GPR25 CTRPv2 pan-cancer AAC 0.26 1e-08
mRNA TRIB2 CTRPv2 pan-cancer AAC 0.31 1e-08
mRNA PPP4R3A GDSC1000 pan-cancer AAC -0.19 1e-08
mRNA TSNAX-DISC1 CTRPv2 pan-cancer AAC 0.28 2e-08
mRNA GFPT2 GDSC1000 pan-cancer AAC 0.18 2e-08
mRNA CNTD1 CTRPv2 pan-cancer AAC 0.27 2e-08
mRNA DCBLD2 GDSC1000 pan-cancer AAC 0.22 2e-08
mRNA ACP5 GDSC1000 pan-cancer AAC 0.21 2e-08
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