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OSI-930

OSI-930

Synonyms

Sources	Names Used
GDSC1000, CTRPv2	OSI-930
PharmacoGx	OSI-930

External IDs

Database	Identifier
Smiles:	FC(F)(F)Oc1ccc(NC(=O)c2sccc2NCc2ccnc3ccccc23)cc1
Pubchem:	9868037

Annotated Targets

KIT, KDR, FLT1

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-930

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZNF138	CTRPv2	pan-cancer	AAC	0.11	0.004
mRNA	ENDOD1	CTRPv2	pan-cancer	AAC	-0.11	0.004
mRNA	BLOC1S5	CTRPv2	pan-cancer	AAC	0.12	0.004
mRNA	SLAMF7	CTRPv2	pan-cancer	AAC	-0.11	0.004
mRNA	PAX7	CTRPv2	pan-cancer	AAC	0.11	0.004
mRNA	RTN1	CTRPv2	pan-cancer	AAC	0.12	0.004
mRNA	SLFN12	CTRPv2	pan-cancer	AAC	-0.11	0.004
mRNA	PCNA	CTRPv2	pan-cancer	AAC	0.11	0.004
mRNA	SETD1B	CTRPv2	pan-cancer	AAC	0.11	0.004
mRNA	TRIM65	GDSC1000	pan-cancer	AAC	0.099	0.004

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