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Compounds
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UNC0638
UNC0638
Synonyms
Sources
Names Used
GDSC1000
,
CTRPv2
UNC0638
PharmacoGx
UNC0638
External IDs
Database
Identifier
Smiles:
CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)C5CCCCC5
Inchikey:
QOECJCJVIMVJGX-UHFFFAOYSA-N
Pubchem:
46224516
Annotated Targets
EHMT1
,
EHMT2
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with UNC0638
(per dataset)
0
100
200
300
400
500
600
700
800
900
1k
# cell lines
CCLE
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
GDSC1000
0
0
0
0
0
830
1047
Download SVG
Number of tissues tested with UNC0638
(per dataset)
0
5
10
15
20
25
30
35
# tissues
CCLE
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
GDSC1000
0
0
0
0
0
25
35
Download SVG
Dataset Select
all
GDSC1000
CTRPv2
UNC0638: AAC
AAC
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
0.55
MY-M12
MY-M12
BC-2
BC-2
JSC-1
JSC-1
KP-N-YS
KP-N-YS
COR-L303
COR-L303
SU-DHL-5
SU-DHL-5
NCI-H748
NCI-H748
P30-OHK
P30-OHK
KARPAS-45
KARPAS-45
HuT 78
HuT 78
DND-41
DND-41
ES5
ES5
CHP-134
CHP-134
ETK-1
ETK-1
EW7476
EW7476
NCI-H865
NCI-H865
IST-SL1
IST-SL1
NCI-H2596
NCI-H2596
MOLP-8
MOLP-8
BC-3
BC-3
H2731
H2731
MKL-2
MKL-2
BT147
BT147
CCRF-CEM
CCRF-CEM
LU-139
LU-139
HH
HH
SBC-1
SBC-1
TE 441.T
TE 441.T
MHH-PREB-1
MHH-PREB-1
PA-1
PA-1
SW620
SW620
NCI-H1623
NCI-H1623
D-283MED
D-283MED
huH-1
huH-1
KP-4
KP-4
Hs-578-T
Hs-578-T
NCI-H1155
NCI-H1155
SNU-1066
SNU-1066
BT145
BT145
DIFI
DIFI
NCI-H2286
NCI-H2286
CL-34
CL-34
KMBC-2
KMBC-2
SK-UT-1
SK-UT-1
LMSU
LMSU
BT224
BT224
DJM-1
DJM-1
EKVX
EKVX
BOKU
BOKU
NCI-H820
NCI-H820
PWR-1E
PWR-1E
Geo
Geo
DLD-1
DLD-1
HEC-50B
HEC-50B
BT179
BT179
T3M-10
T3M-10
BT164
BT164
Gp2D
Gp2D
JHOM-1
JHOM-1
JHUEM-7
JHUEM-7
MY-M12
BC-2
JSC-1
KP-N-YS
COR-L303
SU-DHL-5
NCI-H748
P30-OHK
KARPAS-45
HuT 78
DND-41
ES5
CHP-134
ETK-1
EW7476
NCI-H865
IST-SL1
NCI-H2596
MOLP-8
BC-3
H2731
MKL-2
BT147
CCRF-CEM
LU-139
HH
SBC-1
TE 441.T
MHH-PREB-1
PA-1
SW620
NCI-H1623
D-283MED
huH-1
KP-4
Hs-578-T
NCI-H1155
SNU-1066
BT145
DIFI
NCI-H2286
CL-34
KMBC-2
SK-UT-1
LMSU
BT224
DJM-1
EKVX
BOKU
NCI-H820
PWR-1E
Geo
DLD-1
HEC-50B
BT179
T3M-10
BT164
Gp2D
JHOM-1
JHUEM-7
MY-M12: 0.55
Synonyms: MY-M12
BC-2: 0.48
Synonyms: BC-2
JSC-1: 0.48
Synonyms: JSC-1
KP-N-YS: 0.46
Synonyms: KP-N-YS
COR-L303: 0.39
Synonyms: COR-L303
SU-DHL-5: 0.38
Synonyms: SU-DHL-5
NCI-H748: 0.37
Synonyms: NCI-H748
P30-OHK: 0.37
Synonyms: P30-OHK
KARPAS-45: 0.37
Synonyms: KARPAS-45
HuT 78: 0.36
Synonyms: HuT 78, HuT_78, HUT78
DND-41: 0.36
Synonyms: DND-41, DND41
ES5: 0.35
Synonyms: ES5
CHP-134: 0.35
Synonyms: CHP-134
ETK-1: 0.34
Synonyms: ETK-1
EW7476: 0.33
Synonyms: EW7476
NCI-H865: 0.33
Synonyms: NCI-H865
IST-SL1: 0.33
Synonyms: IST-SL1
NCI-H2596: 0.33
Synonyms: NCI-H2596
MOLP-8: 0.32
Synonyms: MOLP-8, MOLP8
BC-3: 0.32
Synonyms: BC-3
H2731: 0.31
Synonyms: H2731
MKL-2: 0.31
Synonyms: MKL-2
BT147: 0.31
Synonyms: BT147
CCRF-CEM: 0.31
Synonyms: CCRF-CEM, CCRFCEM
LU-139: 0.31
Synonyms: LU-139
HH: 0.31
Synonyms: HH
SBC-1: 0.31
Synonyms: SBC-1
TE 441.T: 0.31
Synonyms: TE 441.T, TE_441.T, TE-441-T, TE441T
MHH-PREB-1: 0.30
Synonyms: MHH-PREB-1
PA-1: 0.30
Synonyms: PA-1
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
SW620: 0.00
Synonyms: SW620, SW 620
NCI-H1623: 0.00
Synonyms: NCI-H1623, NCIH1623
D-283MED: 0.00
Synonyms: D-283MED, D283 Med, D283_Med, D283MED
huH-1: 0.00
Synonyms: huH-1, HUH1
KP-4: 0.00
Synonyms: KP-4, KP4
Hs-578-T: 0.00
Synonyms: Hs-578-T, Hs 578T, Hs_578T, HS578T, hs578t
NCI-H1155: 0.00
Synonyms: NCI-H1155, NCIH1155
SNU-1066: 0.00
Synonyms: SNU-1066, SNU1066
BT145: 0.00
Synonyms: BT145
DIFI: 0.00
Synonyms: DIFI
NCI-H2286: 0.00
Synonyms: NCI-H2286, NCIH2286
CL-34: 0.00
Synonyms: CL-34, CL34
KMBC-2: 0.00
Synonyms: KMBC-2, KMBC2
SK-UT-1: 0.00
Synonyms: SK-UT-1, SKUT1
LMSU: 0.00
Synonyms: LMSU
BT224: 0.00
Synonyms: BT224
DJM-1: 0.00
Synonyms: DJM-1
EKVX: 0.00
Synonyms: EKVX
BOKU: 0.00
Synonyms: BOKU
NCI-H820: 0.00
Synonyms: NCI-H820
PWR-1E: 0.00
Synonyms: PWR-1E
Geo: 0.00
Synonyms: Geo
DLD-1: 0.00
Synonyms: DLD-1, DLD1
HEC-50B: 0.00
Synonyms: HEC-50B, HEC50B
BT179: 0.00
Synonyms: BT179
T3M-10: 0.00
Synonyms: T3M-10, T3M10
BT164: 0.00
Synonyms: BT164
Gp2D: 0.00
Synonyms: Gp2D, GP2d, GP2D
JHOM-1: 0.00
Synonyms: JHOM-1, JHOM1
JHUEM-7: 0.00
Synonyms: JHUEM-7, JHUEM7
Download SVG
0.00
2.00
4.00
6.00
8.00
10.00
12.00
14.00
T98G
T98G
KMM-1
KMM-1
FU-OV-1
FU-OV-1
NCI-H1339
NCI-H1339
BT320
BT320
SNU-1076
SNU-1076
SK-HEP-1
SK-HEP-1
TE-15
TE-15
PLC-PRF-5
PLC-PRF-5
NCI-H1993
NCI-H1993
VM-CUB-1
VM-CUB-1
VMRC-RCZ
VMRC-RCZ
HSC-2
HSC-2
UM-UC-3
UM-UC-3
HOS
HOS
PE/CA-PJ49
PE/CA-PJ49
CAMA-1
CAMA-1
A431
A431
DU-145
DU-145
D-263MG
D-263MG
NCI-H1373
NCI-H1373
Panc 05.04
Panc 05.04
Caki-2
Caki-2
SNU-668
SNU-668
JHOC-5
JHOC-5
CAL-54
CAL-54
BB49-HNC
BB49-HNC
H513
H513
CAL-62
CAL-62
NCI-H1869
NCI-H1869
Hs 729
Hs 729
Toledo
Toledo
JSC-1
JSC-1
IST-SL1
IST-SL1
PEER
PEER
BC-2
BC-2
SW579
SW579
MOLP-8
MOLP-8
MOTN-1
MOTN-1
COV644
COV644
DND-41
DND-41
TE 617.T
TE 617.T
RPMI-8402
RPMI-8402
EoL-1-cell
EoL-1-cell
NCI-H1417
NCI-H1417
OCI-LY10
OCI-LY10
ES5
ES5
ETK-1
ETK-1
KARPAS-45
KARPAS-45
P30-OHK
P30-OHK
DOHH-2
DOHH-2
NALM-6
NALM-6
SU-DHL-5
SU-DHL-5
Ki-JK
Ki-JK
Hs 611.T
Hs 611.T
MY-M12
MY-M12
A673
A673
CRO-AP3
CRO-AP3
Hs 888.T
Hs 888.T
HuT 78
HuT 78
T98G
KMM-1
FU-OV-1
NCI-H1339
BT320
SNU-1076
SK-HEP-1
TE-15
PLC-PRF-5
NCI-H1993
VM-CUB-1
VMRC-RCZ
HSC-2
UM-UC-3
HOS
PE/CA-PJ49
CAMA-1
A431
DU-145
D-263MG
NCI-H1373
Panc 05.04
Caki-2
SNU-668
JHOC-5
CAL-54
BB49-HNC
H513
CAL-62
NCI-H1869
Hs 729
Toledo
JSC-1
IST-SL1
PEER
BC-2
SW579
MOLP-8
MOTN-1
COV644
DND-41
TE 617.T
RPMI-8402
EoL-1-cell
NCI-H1417
OCI-LY10
ES5
ETK-1
KARPAS-45
P30-OHK
DOHH-2
NALM-6
SU-DHL-5
Ki-JK
Hs 611.T
MY-M12
A673
CRO-AP3
Hs 888.T
HuT 78
T98G: 15.71 (log10 µM)
Synonyms: T98G
KMM-1: 9.16 (log10 µM)
Synonyms: KMM-1, KMM1
FU-OV-1: 7.51 (log10 µM)
Synonyms: FU-OV-1, FUOV1
NCI-H1339: 6.85 (log10 µM)
Synonyms: NCI-H1339, NCIH1339
BT320: 5.79 (log10 µM)
Synonyms: BT320
SNU-1076: 5.43 (log10 µM)
Synonyms: SNU-1076, SNU1076
SK-HEP-1: 4.60 (log10 µM)
Synonyms: SK-HEP-1, SKHEP1
TE-15: 4.47 (log10 µM)
Synonyms: TE-15, TE15
PLC-PRF-5: 4.13 (log10 µM)
Synonyms: PLC-PRF-5, PLC/PRF/5, PLC_PRF_5, PLCPRF5
NCI-H1993: 4.03 (log10 µM)
Synonyms: NCI-H1993
VM-CUB-1: 3.89 (log10 µM)
Synonyms: VM-CUB-1, VM-CUB1, VMCUB1
VMRC-RCZ: 3.67 (log10 µM)
Synonyms: VMRC-RCZ, VMRCRCZ
HSC-2: 3.61 (log10 µM)
Synonyms: HSC-2, HSC2
UM-UC-3: 3.59 (log10 µM)
Synonyms: UM-UC-3, UMUC3
HOS: 3.53 (log10 µM)
Synonyms: HOS
PE/CA-PJ49: 3.50 (log10 µM)
Synonyms: PE/CA-PJ49, PE_CA-PJ49, PECAPJ49
CAMA-1: 3.48 (log10 µM)
Synonyms: CAMA-1, CAMA1, cama1
A431: 3.33 (log10 µM)
Synonyms: A431, A-431
DU-145: 3.24 (log10 µM)
Synonyms: DU-145, DU 145, DU_145, DU145
D-263MG: 3.22 (log10 µM)
Synonyms: D-263MG
NCI-H1373: 2.80 (log10 µM)
Synonyms: NCI-H1373, NCIH1373
Panc 05.04: 2.78 (log10 µM)
Synonyms: Panc 05.04, Panc_05.04, PANC0504
Caki-2: 2.70 (log10 µM)
Synonyms: Caki-2, CAKI2
SNU-668: 2.64 (log10 µM)
Synonyms: SNU-668, SNU668
JHOC-5: 2.58 (log10 µM)
Synonyms: JHOC-5, JHOC5
CAL-54: 2.47 (log10 µM)
Synonyms: CAL-54, CAL 54, CAL54
BB49-HNC: 2.46 (log10 µM)
Synonyms: BB49-HNC
H513: 2.44 (log10 µM)
Synonyms: H513
CAL-62: 2.41 (log10 µM)
Synonyms: CAL-62, CAL62
NCI-H1869: 2.37 (log10 µM)
Synonyms: NCI-H1869, NCIH1869
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
Hs 729: 0.45 (log10 µM)
Synonyms: Hs 729, Hs_729, HS729
Toledo: 0.45 (log10 µM)
Synonyms: Toledo, TOLEDO
JSC-1: 0.45 (log10 µM)
Synonyms: JSC-1
IST-SL1: 0.45 (log10 µM)
Synonyms: IST-SL1
PEER: 0.45 (log10 µM)
Synonyms: PEER
BC-2: 0.45 (log10 µM)
Synonyms: BC-2
SW579: 0.44 (log10 µM)
Synonyms: SW579
MOLP-8: 0.44 (log10 µM)
Synonyms: MOLP-8, MOLP8
MOTN-1: 0.43 (log10 µM)
Synonyms: MOTN-1, MOTN1
COV644: 0.43 (log10 µM)
Synonyms: COV644
DND-41: 0.42 (log10 µM)
Synonyms: DND-41, DND41
TE 617.T: 0.41 (log10 µM)
Synonyms: TE 617.T, TE_617.T, TE617T
RPMI-8402: 0.41 (log10 µM)
Synonyms: RPMI-8402, RPMI8402
EoL-1-cell: 0.41 (log10 µM)
Synonyms: EoL-1-cell, EOL-1, EOL1
NCI-H1417: 0.39 (log10 µM)
Synonyms: NCI-H1417
OCI-LY10: 0.39 (log10 µM)
Synonyms: OCI-LY10, OCI-LY-10, OCILY10
ES5: 0.38 (log10 µM)
Synonyms: ES5
ETK-1: 0.36 (log10 µM)
Synonyms: ETK-1
KARPAS-45: 0.35 (log10 µM)
Synonyms: KARPAS-45
P30-OHK: 0.33 (log10 µM)
Synonyms: P30-OHK
DOHH-2: 0.32 (log10 µM)
Synonyms: DOHH-2, DOHH2
NALM-6: 0.31 (log10 µM)
Synonyms: NALM-6, NALM6
SU-DHL-5: 0.31 (log10 µM)
Synonyms: SU-DHL-5
Ki-JK: 0.31 (log10 µM)
Synonyms: Ki-JK, KIJK
Hs 611.T: 0.29 (log10 µM)
Synonyms: Hs 611.T, Hs_611.T, HS611T
MY-M12: 0.24 (log10 µM)
Synonyms: MY-M12
A673: 0.23 (log10 µM)
Synonyms: A673, A-673
CRO-AP3: 0.21 (log10 µM)
Synonyms: CRO-AP3
Hs 888.T: 0.16 (log10 µM)
Synonyms: Hs 888.T, Hs_888.T, HS888T
HuT 78: 0.13 (log10 µM)
Synonyms: HuT 78, HuT_78, HUT78
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
UNC0638: AAC
AAC
Tissues
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
0.55
placenta
placenta
endometrium
endometrium
adrenal_gland
adrenal_gland
oral_cavity
oral_cavity
biliary_tract
biliary_tract
kidney
kidney
large_intestine
large_intestine
cervix
cervix
pancreas
pancreas
upper_aerodigestive_tract
upper_aerodigestive_tract
prostate
prostate
urinary_tract
urinary_tract
thyroid
thyroid
oesophagus
oesophagus
liver
liver
breast
breast
skin
skin
stomach
stomach
ovary
ovary
misc
misc
pleura
pleura
other
other
lung
lung
vulva
vulva
autonomic_ganglia
autonomic_ganglia
central_nervous_system
central_nervous_system
soft_tissue
soft_tissue
unknown
unknown
head_and_neck
head_and_neck
bone
bone
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
small_intestine
small_intestine
neuroblastoma
neuroblastoma
testis
testis
gastrointestinal_tract_(site_indeterminate)
gastrointestinal_tract_(site_indeterminate)
salivary_gland
salivary_gland
0.00
0.20
0.40
0.60
0.80
1.00
1.20
1.40
1.60
1.80
neuroblastoma
neuroblastoma
small_intestine
small_intestine
placenta
placenta
misc
misc
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
bone
bone
biliary_tract
biliary_tract
cervix
cervix
other
other
autonomic_ganglia
autonomic_ganglia
testis
testis
oral_cavity
oral_cavity
head_and_neck
head_and_neck
breast
breast
kidney
kidney
unknown
unknown
soft_tissue
soft_tissue
prostate
prostate
skin
skin
central_nervous_system
central_nervous_system
lung
lung
large_intestine
large_intestine
gastrointestinal_tract_(site_indeterminate)
gastrointestinal_tract_(site_indeterminate)
stomach
stomach
liver
liver
pleura
pleura
pancreas
pancreas
oesophagus
oesophagus
ovary
ovary
thyroid
thyroid
upper_aerodigestive_tract
upper_aerodigestive_tract
vulva
vulva
urinary_tract
urinary_tract
endometrium
endometrium
adrenal_gland
adrenal_gland
salivary_gland
salivary_gland
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to UNC0638
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
ATP6V1B2
GDSC1000
pan-cancer
AAC
0.21
2e-10
mRNA
ZFP36
GDSC1000
pan-cancer
AAC
-0.21
4e-10
mRNA
PLBD1
GDSC1000
pan-cancer
AAC
-0.22
7e-10
mRNA
N4BP2
CTRPv2
pan-cancer
AAC
0.24
3e-09
mRNA
DTNA
GDSC1000
pan-cancer
AAC
0.18
4e-09
mRNA
DNMT3A
CTRPv2
pan-cancer
AAC
0.23
4e-09
mRNA
CYR61
GDSC1000
pan-cancer
AAC
-0.24
6e-09
mRNA
CECR6
GDSC1000
pan-cancer
AAC
0.17
1e-08
mRNA
DCX
GDSC1000
pan-cancer
AAC
0.18
2e-08
mRNA
HEATR5A
GDSC1000
pan-cancer
AAC
-0.18
2e-08
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