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MLN4924

MLN4924

Synonyms

Sources	Names Used
GDSC1000, GRAY	MLN4924
CTRPv2	pevonedistat
PharmacoGx	MLN4924

External IDs

Database	Identifier
Smiles:	C1CC2=CC=CC=C2C1NC3=NC=NC4=C3C=CN4C5CC(C(C5)O)COS(=O)(=O)N
Inchikey:	MPUQHZXIXSTTDU-ZIODWWTISA-N
Pubchem:	71729979

FDA Approval Status

Not Approved

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Top molecular features associated with response to MLN4924

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	GRAMD3	CTRPv2	pan-cancer	AAC	-0.2	4e-08
mRNA	ARL6IP5	CTRPv2	pan-cancer	AAC	-0.19	4e-08
mRNA	SHISA4	CTRPv2	pan-cancer	AAC	-0.23	4e-08
mRNA	PINK1	CTRPv2	pan-cancer	AAC	-0.2	5e-08
mRNA	TOP1MT	CTRPv2	pan-cancer	AAC	0.2	6e-08
mRNA	EXOSC8	CTRPv2	pan-cancer	AAC	0.2	6e-08
mRNA	TIPIN	CTRPv2	pan-cancer	AAC	0.19	6e-08
mRNA	EVI5L	CTRPv2	pan-cancer	AAC	-0.2	6e-08
mRNA	SMPD1	CTRPv2	pan-cancer	AAC	-0.23	6e-08
mRNA	TIMP2	CTRPv2	pan-cancer	AAC	-0.22	7e-08

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