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MLN4924

MLN4924

Synonyms

Sources	Names Used
GDSC1000, GRAY	MLN4924
CTRPv2	pevonedistat
PharmacoGx	MLN4924

External IDs

Database	Identifier
Smiles:	C1CC2=CC=CC=C2C1NC3=NC=NC4=C3C=CN4C5CC(C(C5)O)COS(=O)(=O)N
Inchikey:	MPUQHZXIXSTTDU-ZIODWWTISA-N
Pubchem:	71729979

FDA Approval Status

Not Approved

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Top molecular features associated with response to MLN4924

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	RPS6	CTRPv2	pan-cancer	AAC	0.2	6e-07
mRNA	AURKB	CTRPv2	pan-cancer	AAC	0.17	6e-07
mRNA	MSH5	CTRPv2	pan-cancer	AAC	0.2	6e-07
mRNA	CTDSPL2	CTRPv2	pan-cancer	AAC	0.18	7e-07
mRNA	GOLGA2	CTRPv2	pan-cancer	AAC	-0.18	7e-07
mRNA	PSAP	CTRPv2	pan-cancer	AAC	-0.19	7e-07
mRNA	TGS1	CTRPv2	pan-cancer	AAC	0.18	7e-07
mRNA	WRAP53	CTRPv2	pan-cancer	AAC	0.17	7e-07
mRNA	RRBP1	CTRPv2	pan-cancer	AAC	-0.18	8e-07
mRNA	TMEM127	CTRPv2	pan-cancer	AAC	-0.18	8e-07

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