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MLN4924

MLN4924

Synonyms

Sources	Names Used
GDSC1000, GRAY	MLN4924
CTRPv2	pevonedistat
PharmacoGx	MLN4924

External IDs

Database	Identifier
Smiles:	C1CC2=CC=CC=C2C1NC3=NC=NC4=C3C=CN4C5CC(C(C5)O)COS(=O)(=O)N
Inchikey:	MPUQHZXIXSTTDU-ZIODWWTISA-N
Pubchem:	71729979

FDA Approval Status

Not Approved

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Top molecular features associated with response to MLN4924

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	SMARCC1	CTRPv2	pan-cancer	AAC	0.17	1e-05
mRNA	TM9SF1	CTRPv2	pan-cancer	AAC	-0.16	2e-05
mRNA	KLHL23	CTRPv2	pan-cancer	AAC	0.16	2e-05
mRNA	EWSR1	CTRPv2	pan-cancer	AAC	0.15	2e-05
mRNA	PLK4	CTRPv2	pan-cancer	AAC	0.16	2e-05
mRNA	FXR1	GDSC1000	pan-cancer	AAC	0.17	2e-05
mRNA	TBC1D31	CTRPv2	pan-cancer	AAC	0.15	2e-05
mRNA	TMEM145	CTRPv2	pan-cancer	AAC	0.15	2e-05
mRNA	GTF3C3	GDSC1000	pan-cancer	AAC	0.17	2e-05
mRNA	MTHFD2	CTRPv2	pan-cancer	AAC	0.16	2e-05

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