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GSK1070916

Synonyms

SourcesNames Used
GDSC1000, GRAYGSK1070916
PharmacoGx GSK1070916

External IDs

DatabaseIdentifier
Smiles: CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC(=CC=C5)CN(C)C
Inchikey: QTBWCSQGBMPECM-UHFFFAOYSA-N
Pubchem: 46885626

Annotated Targets

AURKA, AURKB, AURKC, CYP2D6, CYP3A4

FDA Approval Status

Not Approved
Dataset Select
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Top molecular features associated with response to GSK1070916


Feature TypeStandardized
Nominal ANOVA
mRNA MDFI GDSC1000 pan-cancer AAC 0.27 2e-16
mRNA KHDRBS1 GDSC1000 pan-cancer AAC 0.28 2e-16
mRNA HNRNPA1L2 GDSC1000 pan-cancer AAC 0.27 3e-16
mRNA HEATR5A GDSC1000 pan-cancer AAC -0.27 5e-16
mRNA SIL1 GDSC1000 pan-cancer AAC -0.25 6e-16
mRNA FAM117B GDSC1000 pan-cancer AAC 0.27 7e-16
mRNA IGLL1 GDSC1000 pan-cancer AAC 0.28 8e-16
mRNA KDM1A GDSC1000 pan-cancer AAC 0.26 1e-15
mRNA VPREB1 GDSC1000 pan-cancer AAC 0.26 1e-15
mRNA PAN3 GDSC1000 pan-cancer AAC 0.28 1e-15
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