PharmacoDB

Sources

Names Used

Trametinib

GSK1120212

trametinib

PharmacoGx

GSK1120212

Database	Identifier
Smiles:	CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5
Inchikey:	LIRYPHYGHXZJBZ-UHFFFAOYSA-N
Pubchem:	11707110

Database

Identifier

Smiles:

CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5

Inchikey:

LIRYPHYGHXZJBZ-UHFFFAOYSA-N

Pubchem:

Top molecular features associated with response to GSK1120212

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	GJB1	CTRPv2	pan-cancer	AAC	0.24	1e-06
mRNA	RP3-369A17.6	CTRPv2	pan-cancer	AAC	-0.27	1e-06
mRNA	GAS7	CTRPv2	pan-cancer	AAC	0.28	1e-06
mRNA	POU2F2	CTRPv2	pan-cancer	AAC	-0.26	1e-06
mRNA	GGA2	CTRPv2	pan-cancer	AAC	-0.26	1e-06
mRNA	MCOLN2	CTRPv2	pan-cancer	AAC	-0.26	1e-06
mRNA	HNRNPH3	CTRPv2	pan-cancer	AAC	-0.25	2e-06
mRNA	SHPRH	CTRPv2	pan-cancer	AAC	-0.27	2e-06
mRNA	CCNF	CTRPv2	pan-cancer	AAC	-0.24	2e-06
mRNA	HEXA	CTRPv2	pan-cancer	AAC	0.24	2e-06