PharmacoDB

Sources

Names Used

Trametinib

GSK1120212

trametinib

PharmacoGx

GSK1120212

Database	Identifier
Smiles:	CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5
Inchikey:	LIRYPHYGHXZJBZ-UHFFFAOYSA-N
Pubchem:	11707110

Database

Identifier

Smiles:

CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5

Inchikey:

LIRYPHYGHXZJBZ-UHFFFAOYSA-N

Pubchem:

Top molecular features associated with response to GSK1120212

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	CTD-2369P2.10	CTRPv2	pan-cancer	AAC	-0.15	0.003
mRNA	PMS2	CTRPv2	pan-cancer	AAC	-0.15	0.003
mRNA	LAMB1	CTRPv2	pan-cancer	AAC	0.17	0.003
mRNA	ACLY	CTRPv2	pan-cancer	AAC	-0.16	0.003
mRNA	MAGEE1	CTRPv2	pan-cancer	AAC	-0.15	0.003
mRNA	TMEM133	CTRPv2	pan-cancer	AAC	0.15	0.003
mRNA	PQLC2	CTRPv2	pan-cancer	AAC	0.15	0.003
mRNA	UBE2I	CTRPv2	pan-cancer	AAC	-0.15	0.003
mRNA	ZC3H7B	CTRPv2	pan-cancer	AAC	-0.15	0.003
mRNA	KLHL6	CTRPv2	pan-cancer	AAC	-0.19	0.003