PharmacoDB

Sources

Names Used

AZD0530

Saracatinib

saracatinib

PharmacoGx

AZD0530

Database	Identifier
Smiles:	CN1CCN(CC1)CCOC2=CC(=C3C(=C2)N=CN=C3NC4=C(C=CC5=C4OCO5)Cl)OC6CCOCC6
Inchikey:	OUKYUETWWIPKQR-UHFFFAOYSA-N
Pubchem:	10302451

Database

Identifier

Smiles:

CN1CCN(CC1)CCOC2=CC(=C3C(=C2)N=CN=C3NC4=C(C=CC5=C4OCO5)Cl)OC6CCOCC6

Inchikey:

OUKYUETWWIPKQR-UHFFFAOYSA-N

Pubchem:

Top molecular features associated with response to AZD0530

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	TCF7L2	CCLE	pan-cancer	AAC	0.19	0.003
mRNA	ADAMTS9	CCLE	pan-cancer	AAC	0.16	0.003
mRNA	PSEN2	CTRPv2	pan-cancer	AAC	-0.12	0.003
mRNA	GPR22	CCLE	pan-cancer	AAC	-0.14	0.003
mRNA	PDZD4	CTRPv2	pan-cancer	AAC	-0.12	0.003
mRNA	LAMTOR2	CCLE	pan-cancer	AAC	-0.14	0.003
mRNA	C9orf78	CTRPv2	pan-cancer	AAC	-0.11	0.003
mRNA	NF1	CCLE	pan-cancer	AAC	0.14	0.003
mRNA	RGMB	CCLE	pan-cancer	AAC	-0.15	0.003
mRNA	RHEB	CCLE	pan-cancer	AAC	-0.16	0.003