PharmacoDB

Sources

Names Used

TAE684

NVP-TAE684

PharmacoGx

TAE684

Database	Identifier
Smiles:	CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC
Inchikey:	QQWUGDVOUVUTOY-UHFFFAOYSA-N
Pubchem:	16038120

Database

Identifier

Smiles:

CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC

Inchikey:

QQWUGDVOUVUTOY-UHFFFAOYSA-N

Pubchem:

Top molecular features associated with response to TAE684

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	SELPLG	CCLE	pan-cancer	AAC	0.33	9e-09
mRNA	GZMB	CCLE	pan-cancer	AAC	0.24	2e-08
mRNA	MCOLN2	CCLE	pan-cancer	AAC	-0.27	3e-08
mRNA	AMER2	CCLE	pan-cancer	AAC	0.25	3e-08
mRNA	AICDA	CCLE	pan-cancer	AAC	-0.26	4e-08
mRNA	FNDC3B	CCLE	pan-cancer	AAC	0.26	4e-08
mRNA	SASH3	CCLE	pan-cancer	AAC	-0.38	6e-08
mRNA	CD52	CCLE	pan-cancer	AAC	-0.33	7e-08
mRNA	MS4A1	CCLE	pan-cancer	AAC	-0.27	1e-07
mRNA	ACOT12	CCLE	pan-cancer	AAC	0.23	1e-07