About
Documentation
Cite Us!
Github
Download
News
Explore
Batch Query
Search
Site
Home
About
Documentation
PharmacoGx
Cite Us!
Tools
Explore
Batch Query
Search
GitHub
Datatypes
datasets
cell lines
tissues
drugs
genes
experiments
Home
/
Compounds
/
NVP-BEZ235
NVP-BEZ235
Synonyms
Sources
Names Used
GDSC1000
,
GRAY
BEZ235
CTRPv2
NVP-BEZ235
PharmacoGx
NVP-BEZ235
External IDs
Database
Identifier
Smiles:
CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5
Inchikey:
JOGKUKXHTYWRGZ-UHFFFAOYSA-N
Pubchem:
11977753
Annotated Targets
ATR
,
MTOR
,
PIK3CA
,
PIK3CD
,
PIK3CG
,
PIK3CB
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with
NVP-BEZ235 (per dataset)
0
100
200
300
400
500
600
700
800
# cell lines
CCLE
gCSI
FIMM
UHNBreast
GRAY
CTRPv2
GDSC1000
0
0
0
0
50
628
882
Download SVG
Number of tissues tested with NVP-BEZ235
(per dataset)
0
5
10
15
20
25
30
35
# tissues
CCLE
gCSI
FIMM
UHNBreast
GRAY
CTRPv2
GDSC1000
0
0
0
0
1
23
35
Download SVG
Dataset Select
all
GDSC1000
GRAY
CTRPv2
NVP-BEZ235: AAC
AAC
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
RH-41
RH-41
HCC-44
HCC-44
Pfeiffer
Pfeiffer
BPH-1
BPH-1
OSC-20
OSC-20
OCI-LY3
OCI-LY3
BCP-1
BCP-1
MKN1
MKN1
BL-70
BL-70
NCI-H2030
NCI-H2030
RI-1
RI-1
HUTU-80
HUTU-80
Ramos-2G6-4C10
Ramos-2G6-4C10
H2591
H2591
MFE-319
MFE-319
KMS-34
KMS-34
Hs 611.T
Hs 611.T
JHUEM-7
JHUEM-7
RCC-JW
RCC-JW
SK-N-MC
SK-N-MC
EB1
EB1
SU-DHL-6
SU-DHL-6
BHY
BHY
HN
HN
SU-DHL-5
SU-DHL-5
DV-90
DV-90
IMR-32
IMR-32
697
697
OE21
OE21
EMC-BAC-2
EMC-BAC-2
IMR-5
IMR-5
CI-1
CI-1
IM-9
IM-9
NB(TU)1-10
NB(TU)1-10
BT498
BT498
LU-165
LU-165
NB10
NB10
NCI-H2066
NCI-H2066
NCI-H630
NCI-H630
KM-H2
KM-H2
Mino
Mino
JHOS-4
JHOS-4
NCI-H2141
NCI-H2141
PCI-15A
PCI-15A
SHP-77
SHP-77
OVMIU
OVMIU
NCI-H1993
NCI-H1993
Caov-4
Caov-4
UDSCC2
UDSCC2
REC-1
REC-1
LAN-6
LAN-6
QGP-1
QGP-1
Geo
Geo
NCI-H2135
NCI-H2135
NUGC-4
NUGC-4
NCI-H1304
NCI-H1304
LB373-MEL-D
LB373-MEL-D
C3A
C3A
JHH-6
JHH-6
NCI-H1836
NCI-H1836
RH-41
HCC-44
Pfeiffer
BPH-1
OSC-20
OCI-LY3
BCP-1
MKN1
BL-70
NCI-H2030
RI-1
HUTU-80
Ramos-2G6-4C10
H2591
MFE-319
KMS-34
Hs 611.T
JHUEM-7
RCC-JW
SK-N-MC
EB1
SU-DHL-6
BHY
HN
SU-DHL-5
DV-90
IMR-32
697
OE21
EMC-BAC-2
IMR-5
CI-1
IM-9
NB(TU)1-10
BT498
LU-165
NB10
NCI-H2066
NCI-H630
KM-H2
Mino
JHOS-4
NCI-H2141
PCI-15A
SHP-77
OVMIU
NCI-H1993
Caov-4
UDSCC2
REC-1
LAN-6
QGP-1
Geo
NCI-H2135
NUGC-4
NCI-H1304
LB373-MEL-D
C3A
JHH-6
NCI-H1836
RH-41: 0.79
Synonyms: RH-41, RH41
HCC-44: 0.78
Synonyms: HCC-44, HCC44
Pfeiffer: 0.75
Synonyms: Pfeiffer, PFEIFFER
BPH-1: 0.75
Synonyms: BPH-1
OSC-20: 0.72
Synonyms: OSC-20
OCI-LY3: 0.71
Synonyms: OCI-LY3, OCI-LY-3, OCILY3
BCP-1: 0.71
Synonyms: BCP-1, BCP1
MKN1: 0.70
Synonyms: MKN1, MKN-1
BL-70: 0.70
Synonyms: BL-70, BL70
NCI-H2030: 0.68
Synonyms: NCI-H2030, NCIH2030
RI-1: 0.68
Synonyms: RI-1, RI1
HUTU-80: 0.68
Synonyms: HUTU-80, HuTu 80, HuTu_80
Ramos-2G6-4C10: 0.66
Synonyms: Ramos-2G6-4C10
H2591: 0.66
Synonyms: H2591
MFE-319: 0.65
Synonyms: MFE-319, MFE319
KMS-34: 0.64
Synonyms: KMS-34, KMS34
Hs 611.T: 0.64
Synonyms: Hs 611.T, Hs_611.T, HS611T
JHUEM-7: 0.64
Synonyms: JHUEM-7, JHUEM7
RCC-JW: 0.64
Synonyms: RCC-JW
SK-N-MC: 0.61
Synonyms: SK-N-MC, SKNMC
EB1: 0.61
Synonyms: EB1
SU-DHL-6: 0.61
Synonyms: SU-DHL-6, SUDHL6
BHY: 0.61
Synonyms: BHY
HN: 0.60
Synonyms: HN
SU-DHL-5: 0.59
Synonyms: SU-DHL-5
DV-90: 0.59
Synonyms: DV-90, DV90
IMR-32: 0.59
Synonyms: IMR-32, IMR32
697: 0.59
Synonyms: 697
OE21: 0.58
Synonyms: OE21
EMC-BAC-2: 0.58
Synonyms: EMC-BAC-2
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
IMR-5: 0.05
Synonyms: IMR-5
CI-1: 0.05
Synonyms: CI-1, CI1
IM-9: 0.05
Synonyms: IM-9
NB(TU)1-10: 0.05
Synonyms: NB(TU)1-10
BT498: 0.05
Synonyms: BT498
LU-165: 0.05
Synonyms: LU-165
NB10: 0.04
Synonyms: NB10
NCI-H2066: 0.04
Synonyms: NCI-H2066
NCI-H630: 0.04
Synonyms: NCI-H630
KM-H2: 0.04
Synonyms: KM-H2, KMH2
Mino: 0.04
Synonyms: Mino, MINO
JHOS-4: 0.04
Synonyms: JHOS-4
NCI-H2141: 0.03
Synonyms: NCI-H2141, NCIH2141
PCI-15A: 0.02
Synonyms: PCI-15A
SHP-77: 0.02
Synonyms: SHP-77, SHP77
OVMIU: 0.02
Synonyms: OVMIU
NCI-H1993: 0.02
Synonyms: NCI-H1993
Caov-4: 0.02
Synonyms: Caov-4
UDSCC2: 0.02
Synonyms: UDSCC2
REC-1: 0.02
Synonyms: REC-1, REC1
LAN-6: 0.02
Synonyms: LAN-6
QGP-1: 0.02
Synonyms: QGP-1, QGP1
Geo: 0.01
Synonyms: Geo
NCI-H2135: 0.01
Synonyms: NCI-H2135
NUGC-4: 0.01
Synonyms: NUGC-4, NUGC4
NCI-H1304: 0.01
Synonyms: NCI-H1304
LB373-MEL-D: 0.01
Synonyms: LB373-MEL-D
C3A: 0.00
Synonyms: C3A
JHH-6: 0.00
Synonyms: JHH-6, JHH6
NCI-H1836: 0.00
Synonyms: NCI-H1836
Download SVG
-3.00
-2.00
-1.00
0.00
1.00
2.00
3.00
4.00
5.00
6.00
7.00
Malme-3M
Malme-3M
NCI-H727
NCI-H727
REC-1
REC-1
HSC-4
HSC-4
TUHR10TKB
TUHR10TKB
SW1116
SW1116
BT-483
BT-483
Sq-1
Sq-1
ZR-75-30
ZR-75-30
Hs 944.T
Hs 944.T
MJ
MJ
EFO-21
EFO-21
SK-MEL-3
SK-MEL-3
Capan-2
Capan-2
KNS-60
KNS-60
HuP-T3
HuP-T3
SU.86.86
SU.86.86
CCF-STTG1
CCF-STTG1
EN
EN
NCI-H1573
NCI-H1573
BICR 56
BICR 56
MKN74
MKN74
Toledo
Toledo
WM-983B
WM-983B
J82
J82
A498
A498
ARH-77
ARH-77
A253
A253
NCI-H358
NCI-H358
UACC-62
UACC-62
JHUEM-7
JHUEM-7
Hs-633T
Hs-633T
SU-DHL-5
SU-DHL-5
HEY
HEY
EC-GI-10
EC-GI-10
KON
KON
BCP-1
BCP-1
Ramos-2G6-4C10
Ramos-2G6-4C10
HN
HN
AN3-CA
AN3-CA
PC-3
PC-3
EMC-BAC-2
EMC-BAC-2
GRANTA-519
GRANTA-519
RI-1
RI-1
OSC-19
OSC-19
ETK-1
ETK-1
Hs 611.T
Hs 611.T
EB1
EB1
OV-90
OV-90
MFE-319
MFE-319
42-MG-BA
42-MG-BA
Pfeiffer
Pfeiffer
RCC-AB
RCC-AB
RCC-JW
RCC-JW
Daudi
Daudi
OCI-LY3
OCI-LY3
AM-38
AM-38
TOV-21G
TOV-21G
HUTU-80
HUTU-80
MKN1
MKN1
Malme-3M
NCI-H727
REC-1
HSC-4
TUHR10TKB
SW1116
BT-483
Sq-1
ZR-75-30
Hs 944.T
MJ
EFO-21
SK-MEL-3
Capan-2
KNS-60
HuP-T3
SU.86.86
CCF-STTG1
EN
NCI-H1573
BICR 56
MKN74
Toledo
WM-983B
J82
A498
ARH-77
A253
NCI-H358
UACC-62
JHUEM-7
Hs-633T
SU-DHL-5
HEY
EC-GI-10
KON
BCP-1
Ramos-2G6-4C10
HN
AN3-CA
PC-3
EMC-BAC-2
GRANTA-519
RI-1
OSC-19
ETK-1
Hs 611.T
EB1
OV-90
MFE-319
42-MG-BA
Pfeiffer
RCC-AB
RCC-JW
Daudi
OCI-LY3
AM-38
TOV-21G
HUTU-80
MKN1
Malme-3M: 7.22 (log10 µM)
Synonyms: Malme-3M, MALME3M
NCI-H727: 3.68 (log10 µM)
Synonyms: NCI-H727, NCIH727
REC-1: 3.35 (log10 µM)
Synonyms: REC-1, REC1
HSC-4: 3.17 (log10 µM)
Synonyms: HSC-4, HSC4
TUHR10TKB: 2.75 (log10 µM)
Synonyms: TUHR10TKB
SW1116: 2.51 (log10 µM)
Synonyms: SW1116, SW 1116
BT-483: 2.51 (log10 µM)
Synonyms: BT-483, BT483, bt483
Sq-1: 1.95 (log10 µM)
Synonyms: Sq-1, SQ1
ZR-75-30: 1.95 (log10 µM)
Synonyms: ZR-75-30, ZR7530, zr7530
Hs 944.T: 1.75 (log10 µM)
Synonyms: Hs 944.T, Hs_944.T, Hs-944-T, HS944T
MJ: 1.61 (log10 µM)
Synonyms: MJ
EFO-21: 1.60 (log10 µM)
Synonyms: EFO-21, EFO21
SK-MEL-3: 1.58 (log10 µM)
Synonyms: SK-MEL-3, SKMEL3
Capan-2: 1.47 (log10 µM)
Synonyms: Capan-2, CAPAN2
KNS-60: 1.45 (log10 µM)
Synonyms: KNS-60, KNS60
HuP-T3: 1.42 (log10 µM)
Synonyms: HuP-T3, HUP-T3, HUPT3
SU.86.86: 1.32 (log10 µM)
Synonyms: SU.86.86, SU8686
CCF-STTG1: 1.27 (log10 µM)
Synonyms: CCF-STTG1, CCFSTTG1
EN: 1.07 (log10 µM)
Synonyms: EN
NCI-H1573: 0.94 (log10 µM)
Synonyms: NCI-H1573, NCIH1573
BICR 56: 0.87 (log10 µM)
Synonyms: BICR 56, BICR_56, BICR56
MKN74: 0.84 (log10 µM)
Synonyms: MKN74, MKN-74
Toledo: 0.78 (log10 µM)
Synonyms: Toledo, TOLEDO
WM-983B: 0.63 (log10 µM)
Synonyms: WM-983B, WM983B
J82: 0.61 (log10 µM)
Synonyms: J82
A498: 0.55 (log10 µM)
Synonyms: A498, A-498
ARH-77: 0.52 (log10 µM)
Synonyms: ARH-77
A253: 0.49 (log10 µM)
Synonyms: A253, A-253
NCI-H358: 0.48 (log10 µM)
Synonyms: NCI-H358, NCIH358
UACC-62: 0.44 (log10 µM)
Synonyms: UACC-62, UACC62
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
JHUEM-7: -2.12 (log10 µM)
Synonyms: JHUEM-7, JHUEM7
Hs-633T: -2.13 (log10 µM)
Synonyms: Hs-633T, Hs633T
SU-DHL-5: -2.13 (log10 µM)
Synonyms: SU-DHL-5
HEY: -2.13 (log10 µM)
Synonyms: HEY, Hey
EC-GI-10: -2.13 (log10 µM)
Synonyms: EC-GI-10, ECGI10
KON: -2.17 (log10 µM)
Synonyms: KON
BCP-1: -2.18 (log10 µM)
Synonyms: BCP-1, BCP1
Ramos-2G6-4C10: -2.21 (log10 µM)
Synonyms: Ramos-2G6-4C10
HN: -2.25 (log10 µM)
Synonyms: HN
AN3-CA: -2.25 (log10 µM)
Synonyms: AN3-CA, AN3 CA, AN3_CA, AN3CA
PC-3: -2.26 (log10 µM)
Synonyms: PC-3, PC3
EMC-BAC-2: -2.28 (log10 µM)
Synonyms: EMC-BAC-2
GRANTA-519: -2.29 (log10 µM)
Synonyms: GRANTA-519, GRANTA519
RI-1: -2.30 (log10 µM)
Synonyms: RI-1, RI1
OSC-19: -2.30 (log10 µM)
Synonyms: OSC-19
ETK-1: -2.30 (log10 µM)
Synonyms: ETK-1
Hs 611.T: -2.32 (log10 µM)
Synonyms: Hs 611.T, Hs_611.T, HS611T
EB1: -2.33 (log10 µM)
Synonyms: EB1
OV-90: -2.35 (log10 µM)
Synonyms: OV-90, OV90
MFE-319: -2.36 (log10 µM)
Synonyms: MFE-319, MFE319
42-MG-BA: -2.37 (log10 µM)
Synonyms: 42-MG-BA, 42MGBA
Pfeiffer: -2.38 (log10 µM)
Synonyms: Pfeiffer, PFEIFFER
RCC-AB: -2.44 (log10 µM)
Synonyms: RCC-AB
RCC-JW: -2.49 (log10 µM)
Synonyms: RCC-JW
Daudi: -2.52 (log10 µM)
Synonyms: Daudi, DAUDI
OCI-LY3: -2.53 (log10 µM)
Synonyms: OCI-LY3, OCI-LY-3, OCILY3
AM-38: -2.57 (log10 µM)
Synonyms: AM-38, AM38
TOV-21G: -2.60 (log10 µM)
Synonyms: TOV-21G, TOV21G
HUTU-80: -2.76 (log10 µM)
Synonyms: HUTU-80, HuTu 80, HuTu_80
MKN1: -3.01 (log10 µM)
Synonyms: MKN1, MKN-1
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
NVP-BEZ235: AAC
AAC
Tissues
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
neuroblastoma
neuroblastoma
cervix
cervix
other
other
breast
breast
large_intestine
large_intestine
placenta
placenta
unknown
unknown
lung
lung
skin
skin
autonomic_ganglia
autonomic_ganglia
testis
testis
pancreas
pancreas
oesophagus
oesophagus
pleura
pleura
liver
liver
stomach
stomach
salivary_gland
salivary_gland
urinary_tract
urinary_tract
prostate
prostate
endometrium
endometrium
central_nervous_system
central_nervous_system
upper_aerodigestive_tract
upper_aerodigestive_tract
ovary
ovary
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
kidney
kidney
vulva
vulva
thyroid
thyroid
soft_tissue
soft_tissue
bone
bone
head_and_neck
head_and_neck
oral_cavity
oral_cavity
biliary_tract
biliary_tract
adrenal_gland
adrenal_gland
misc
misc
small_intestine
small_intestine
-3.00
-2.00
-1.00
0.00
1.00
2.00
3.00
4.00
small_intestine
small_intestine
misc
misc
biliary_tract
biliary_tract
head_and_neck
head_and_neck
vulva
vulva
prostate
prostate
pleura
pleura
kidney
kidney
bone
bone
thyroid
thyroid
placenta
placenta
salivary_gland
salivary_gland
adrenal_gland
adrenal_gland
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
central_nervous_system
central_nervous_system
oral_cavity
oral_cavity
stomach
stomach
other
other
autonomic_ganglia
autonomic_ganglia
ovary
ovary
soft_tissue
soft_tissue
urinary_tract
urinary_tract
oesophagus
oesophagus
upper_aerodigestive_tract
upper_aerodigestive_tract
endometrium
endometrium
cervix
cervix
pancreas
pancreas
skin
skin
large_intestine
large_intestine
lung
lung
liver
liver
breast
breast
unknown
unknown
testis
testis
neuroblastoma
neuroblastoma
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to NVP-BEZ235
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
FLNB
GDSC1000
pan-cancer
AAC
0.13
0.003
mRNA
COX4I2
CTRPv2
pan-cancer
AAC
-0.12
0.003
mRNA
KLK11
GDSC1000
pan-cancer
AAC
-0.1
0.003
mRNA
LUZP1
GDSC1000
pan-cancer
AAC
0.11
0.003
mRNA
RELT
GDSC1000
pan-cancer
AAC
-0.11
0.003
mRNA
C11orf70
GDSC1000
pan-cancer
AAC
0.11
0.003
mRNA
TRIM9
GDSC1000
pan-cancer
AAC
-0.11
0.003
mRNA
SPCS3
GDSC1000
pan-cancer
AAC
0.1
0.003
mRNA
PPP1R36
GDSC1000
pan-cancer
AAC
-0.11
0.003
mRNA
ADGRE5
GDSC1000
pan-cancer
AAC
0.11
0.003
← Previous
1
2
…
182
183
184
…
199
200
Next →
Download CSV