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NVP-BEZ235

Synonyms

SourcesNames Used
GDSC1000, GRAYBEZ235
CTRPv2NVP-BEZ235
PharmacoGx NVP-BEZ235

External IDs

DatabaseIdentifier
Smiles: CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5
Inchikey: JOGKUKXHTYWRGZ-UHFFFAOYSA-N
Pubchem: 11977753

Annotated Targets

ATR, MTOR, PIK3CA, PIK3CD, PIK3CG, PIK3CB

FDA Approval Status

Not Approved
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Top molecular features associated with response to NVP-BEZ235


Feature TypeStandardized
Nominal ANOVA
mRNA SCG3 GDSC1000 pan-cancer AAC -0.23 5e-09
mRNA UNC80 GDSC1000 pan-cancer AAC -0.21 6e-09
mRNA E2F5 CTRPv2 pan-cancer AAC 0.25 7e-09
mRNA CLDN3 GDSC1000 pan-cancer AAC -0.25 9e-09
mRNA IGFBP6 GDSC1000 pan-cancer AAC 0.24 1e-08
mRNA NRSN1 GDSC1000 pan-cancer AAC -0.22 2e-08
mRNA RHOH CTRPv2 pan-cancer AAC 0.28 2e-08
mRNA ADCY1 GDSC1000 pan-cancer AAC -0.22 3e-08
mRNA CHMP7 GDSC1000 pan-cancer AAC 0.2 3e-08
mRNA TGFB1I1 GDSC1000 pan-cancer AAC 0.23 3e-08
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